Evidence map›Paper›PMID 19327639›Full record

ArticleOral surgery, oral medicine, oral pathology, oral radiology, and endodontics2009

Identification of novel fibroblast growth factor receptor 3 gene mutations in actinic cheilitis and squamous cell carcinoma of the lip.

Annie Chou, Nusi Dekker, Richard C K Jordan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Lip cancer and pre-cancerous lesions harbor TP53 mutations, exhibit allelic loss at 9p, 9q, and 17p, but no BRAFV600E mutations.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Article
  3. Review
  4. Article
  5. Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers.Apoptosis : an international journal on programmed cell death · 2013
    Review
  6. Mutational Status of FGFR3 in Oral Squamous Cell Carcinoma.Journal of dentistry (Tehran, Iran) · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Annie ChouDepartment of Orofacial Sciences, University of California, San Francisco, California 94143-0424, USA.
Nusi Dekker
Richard C K Jordan
University of California, San Francisco · US

Funding

Oral &Craniofacial Sciences-Clinical and Translational Sciences TrainingT32DE017249 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JORDAN, RICHARD C · 2005 to 2010
$1.8M
Molecular Predictors of Oral Cancer DevelopmentR33CA095231 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JORDAN, RICHARD C · 2004 to 2006
$1.1M
Molecular predictors of oral cancer developmentR21CA095231 · NCI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI JORDAN, RICHARD C · 2002 to 2003
$322k
NCI NIH HHS CA095231NCI NIH HHS R21 CA095231NCI NIH HHS R33 CA095231NIDCR NIH HHS T32 DE017249NIDCR NIH HHS T32DE017249
6 · The paper itself

Abstract

objectiveActivating mutations in the fibroblast growth factor receptor 3 (FGFR3) gene are responsible for several craniosynostosis and chondrodysplasia syndromes as well as some human cancers, including bladder and cervical carcinoma. Despite a high frequency in some benign skin disorders, FGFR3 mutations have not been reported in cutaneous malignancies. Actinic cheilitis (AC) is a sun-induced premalignancy affecting the lower lip that frequently progresses to squamous cell carcinoma (SCC). The objective of this study was to determine if FGFR3 gene mutations are present in AC and SCC of the lip. STUDY

designDNA was extracted and purified from microdissected, formalin-fixed, paraffin-embedded tissue sections of 20 cases of AC and SCC arising in AC. Exons 7, 15, and 17 were PCR amplified and direct sequenced.

resultsFour novel somatic mutations in the FGFR3 gene were identified: exon 7 mutation 742C-->T (amino acid change R248C), exon 15 mutations 1850A-->G (D617G) and 1888G-->A (V630M), and exon 17 mutation 2056G-->A (E686K). Grade of dysplasia did not correlate with presence of mutations.

conclusionThe frequency of FGFR3 receptor mutations suggests a functional role for the FGFR3 receptor in the development of epithelial disorders, and perhaps this change may contribute to the pathogenesis of some AC and SCC.

Indexed as

AdultAgedAged, 80 and overCarcinoma, Squamous CellCheilitisDNA Mutational AnalysisHumansImmunoenzyme TechniquesLip NeoplasmsMaleMiddle AgedPoint MutationPolymerase Chain ReactionPolymorphism, Single NucleotideReceptor, Fibroblast Growth Factor, Type 3SunlightReceptor, Fibroblast Growth Factor, Type 3

Identifiers

PMID19327639
PMCPMC2682427
OpenAlexW2058389440

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.