ReviewHematology/oncology clinics of North America2009
Congenital amegakaryocytic thrombocytopenia and thrombocytopenia with absent radii.
Review in Hematology/oncology clinics of North America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 89 citations in OpenAlex.
- Molecular diagnosis of inherited platelet disorders: a tale of two realities - advanced vs. resource-limited setting.Thrombosis journal · 2025Review
- Persistent Thrombocytopenia in a Well Newborn: Looking Beyond Neonatal Alloimmune Thrombocytopenia.Indian journal of pediatrics · 2023Article
- Selective T-cell depletion targeting CD45RA as a novel approach for HLA-mismatched hematopoietic stem cell transplantation in pediatric nonmalignant hematological diseases.International journal of hematology · 2021Article
- Distinguishing constitutional from acquired bone marrow failure in the hematology clinic.Best practice & research. Clinical haematology · 2021Review
- C-Cbl regulates c-MPL receptor trafficking and its internalization.Journal of cellular and molecular medicine · 2020Article
- Changes in megakaryopoiesis over ontogeny and their implications in health and disease.Platelets · 2020Review
- Megakaryocytes as immune cells.Journal of leukocyte biology · 2019Review
- Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice.Thrombosis and haemostasis · 2017Article
- Inherited thrombocytopenias in the era of personalized medicine.Haematologica · 2015Article
- Advances in genetic studies of inherited bone marrow failure syndromes and their associated malignancies.Translational pediatrics · 2014Review
- Genetics of familial forms of thrombocytopenia.Human genetics · 2012Review
- T-cell-depleted hematopoietic SCT from unrelated donors for the treatment of congenital amegakaryocytic thrombocytopenia.Bone marrow transplantation · 2012Article
- Two patterns of thrombopoietin signaling suggest no coupling between platelet production and thrombopoietin reactivity in thrombocytopenia-absent radii syndrome.Haematologica · 2012Article
- Article
- Increasing platelets without transfusion: is it time to introduce novel thrombopoietic agents in neonatal care?Journal of perinatology : official journal of the California Perinatal Association · 2010Article
- Pathophysiology and management of inherited bone marrow failure syndromes.Blood reviews · 2010Review
- Article
- Clinical approach to marrow failure.Hematology. American Society of Hematology. Education Program · 2009Review
- Thrombocytopenia-absent radius syndrome: prenatal diagnosis of a rare syndrome.Radiologia brasileiraArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Thrombocytopenia is a relatively common clinical problem in hospitalized neonates, and it is critical to distinguish infants who have rare congenital thrombocytopenias from those who have acquired disorders. Two well-described inherited thrombocytopenia syndromes that present in the newborn period are congenital amegakaryocytic thrombocytopenia (CAMT) and thrombocytopenia with absent radii (TAR). Although both are characterized by severe (< 50,000/microL) thrombocytopenia at birth, the molecular mechanisms underlying these disorders and their clinical presentations and courses are distinct. CAMT is an autosomal recessive disorder caused by mutations in the thrombopoietin (TPO) receptor c-Mpl. TAR is a syndrome of variable inheritance and unclear genetic etiology consisting of thrombocytopenia in association with bilateral absent radii and frequently additional congenital abnormalities. This article summarizes the current understanding of the pathophysiology and clinical course of CAMT and TAR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.