ArticleJournal of experimental & clinical cancer research : CR2009
CDK4 IVS4-nt40 AA genotype and obesity-associated tumors/cancer in Italians - a case-control study.
Article in Journal of experimental & clinical cancer research : CR, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- T2D and Depression Risk Gene Proteasome Modulator 9 is Linked to Insomnia.Scientific reports · 2015Article
- Overweight condition and waist circumference and a candidate gene within the 12q24 locus.Cardiovascular diabetology · 2013Article
- Re-thinking cell cycle regulators: the cross-talk with metabolism.Frontiers in oncology · 2013Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundCell cycle checkpoint regulation is crucial for prevention of tumor in mammalian cells. Cyclin-dependant kinase 4 (CDK4) is important in cell cycle regulation, as it controls the G1-S phase of the cell cycle. CDK4 has potential mitogenic properties through phosphorylation of target proteins. We aimed at identifying a role of CDK4 IVS4-nt40 G-->A gene variant in benign and/or malignant tumors and in obesity-associated benign and/or malignant tumors in an Italian adult subject dataset.
methodsWe recruited 263 unrelated Italian subjects: 106 subjects had at least one benign tumor and 46 subjects had at least one malignant tumor, while 116 subjects had at least two tumors and/or cancers. We collected BMI data for 90% of them: 186 subjects had a BMI>or=30 Kg/m2 and 52 subjects had a BMI >or= 30 Kg/m2. We performed statistical power calculations in our datasets. DNA samples were directly sequenced with specific primers for the CDK4 IVS4-nt40 G-->A variant. Genotype association tests with disease were performed.
resultsIn our study, no significant association of the CDK4 IVS4-nt40 AA genotype with cancer and/or tumors/cancer are/is detected. However, the CDK4 IVS4-nt40 AA genotype is significantly associated with cancer and tumors/cancer in obese patients.
conclusionThis finding is interesting since obesity is a risk factor for tumors and cancer. This study should prompt further work aiming at establishing the role of CDK4 in contributing to tumor/cancer genetic risk predisposition, as well as its role as a potentially effective therapeutic target gene for obesity-associated tumor/cancer management.
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