Evidence map›Paper›PMID 19327116›Full record

ReviewFuture microbiology2009

CCAAT/enhancer-binding proteins and the pathogenesis of retrovirus infection.

Yujie Liu, Michael R Nonnemacher, Brian Wigdahl

Open access · greenAbstract readReview
In one paragraph

Review in Future microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Observational
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  12. Article
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Yujie LiuDepartment of Microbiology & Immunology, Center for Molecular Virology & Neuroimmunology, Center for Cancer Biology, Philadelphia, PA 19129, USA.
Michael R Nonnemacher
Brian Wigdahl
Institute of Neuroimmunology of the Slovak Academy of Sciences · SK

Funding

High Specificity HIV-1 Markers Predictive of Neuro-AIDSR01DA019807 · NIDA · DREXEL UNIVERSITY · PI WIGDAHL, BRIAN · 2004 to 2014
$5.1M
NEUROLOGICAL &LYMPHOID FACTORS IN HIV1 LTR ACTIVATIONR01NS032092 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI WIGDAHL, BRIAN · 1993 to 2011
$3.9M
Co-evolution of HIV-1 Regulators in CNS DiseaseR01NS046263 · NINDS · DREXEL UNIVERSITY · PI WIGDAHL, BRIAN · 2004 to 2009
$1.8M
NIDA NIH HHS R01 DA019807NINDS NIH HHS R01 NS032092NINDS NIH HHS R01 NS046263
6 · The paper itself

Abstract

Previous studies indicate that two upstream CCAAT/enhancer-binding protein (C/EBP) sites and C/EBPbeta are required for subtype B HIV-1 gene expression in cells of the monocyte-macrophage lineage. The mechanisms of C/EBP regulation of HIV-1 transcription and replication remain unclear. This review focuses on studies concerning the role of C/EBP factors in HIV-1, human T-cell leukemia virus type 1, and SIV transcription in various cell types and tissues cultured in vitro, animal models and during human infection. The structure and function of the C/EBPbeta gene and the related protein isoforms are discussed along with the transcription factors, coactivators, viral proteins, cytokines and chemokines that affect C/EBP function.

Indexed as

HIV InfectionsAnimalsCCAAT-Enhancer-Binding Protein-betaChemokinesEnhancer Elements, GeneticEnzyme ActivationGene Expression Regulation, ViralHIV-1HTLV-I InfectionsHumansProtein IsoformsProtein Structure, TertiaryReceptors, CCR5Simian Acquired Immunodeficiency SyndromeTranscriptional ActivationVirus ReplicationCCAAT-Enhancer-Binding Protein-betaChemokinesProtein IsoformsReceptors, CCR5

Identifiers

PMID19327116
PMCPMC2710768
OpenAlexW2046350038

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.