ArticleThe Journal of comparative neurology2009
Distribution of EphA5 receptor protein in the developing and adult mouse nervous system.
Article in The Journal of comparative neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
- Essential function of Nr4a2 in subicular development and social novelty.Journal of advanced research · 2026Article
- Trigeminal Nerve and Vestibular System: Update on Pathophysiological and Clinical Links.Audiology research · 2025Review
- Unveiling the Therapeutic Potential: A Peptide Drug Conjugate's Influence on Transcription and Translation in Ocular Fibrosis Modulation.ACS omega · 2025Article
- Review
- Establishing functionally segregated dopaminergic circuits.Trends in neurosciences · 2025Review
- 1800 MHz Radiofrequency Electromagnetic Field Impairs Neurite Outgrowth Through Inhibiting EPHA5 Signaling.Frontiers in cell and developmental biology · 2021Article
- Neurogenesis From Neural Crest Cells: Molecular Mechanisms in the Formation of Cranial Nerves and Ganglia.Frontiers in cell and developmental biology · 2020Review
- Development and Arealization of the Cerebral Cortex.Neuron · 2019Review
- Differential expression of EphA5 protein in gastric carcinoma and its clinical significance.Oncology letters · 2019Article
- Dynamic Alterations of Retinal EphA5 Expression in Retinocollicular Map Plasticity.Developmental neurobiology · 2019Article
- Article
- c-Fos downregulation positively regulates EphA5 expression in a congenital hypothyroidism rat model.Journal of molecular histology · 2018Article
- Novel Roles and Mechanism for Krüppel-like Factor 16 (KLF16) Regulation of Neurite Outgrowth and Ephrin Receptor A5 (EphA5) Expression in Retinal Ganglion Cells.The Journal of biological chemistry · 2016Article
- DNA Methylation of the EphA5 Promoter Is Associated with Rat Congenital Hypothyroidism.Journal of molecular neuroscience : MN · 2015Article
- Article
- Rapid Changes in Cortical and Subcortical Brain Regions after Early Bilateral Enucleation in the Mouse.PloS one · 2015Article
- Ablation of ErbB4 from excitatory neurons leads to reduced dendritic spine density in mouse prefrontal cortex.The Journal of comparative neurology · 2014Article
- Formation of persistent hyperplastic primary vitreous in ephrin-A5-/- mice.Investigative ophthalmology & visual science · 2014Article
- Forced swim test induces divergent global transcriptomic alterations in the hippocampus of high versus low novelty-seeker rats.Human genomics · 2014Article
- Amygdala nuclei critical for emotional learning exhibit unique gene expression patterns.Neurobiology of learning and memory · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The EphA5 receptor tyrosine kinase plays key roles in axon guidance during development. However, the presence of EphA5 protein in the nervous system has not been fully characterized. To examine EphA5 localization better, mutant mice, in which the EphA5 cytoplasmic domain was replaced with beta-galactosidase, were analyzed for both temporal and regional changes in the distribution of EphA5 protein in the developing and adult nervous system. During embryonic development, high levels of EphA5 protein were found in the retina, olfactory bulb, cerebral neocortex, hippocampus, pretectum, tectum, cranial nerve nuclei, and spinal cord. Variations in intensity were observed as development proceeded. Staining of pretectal nuclei, tectal nuclei, and other areas of the mesencephalon became more diffuse after maturity, whereas the cerebral neocortex gained more robust intensity. In the adult, receptor protein continued to be detected in many areas including the olfactory nuclei, neocortex, piriform cortex, induseum griseum, hippocampus, thalamus, amygdala, hypothalamus, and septum. In addition, EphA5 protein was found in the claustrum, stria terminalis, barrel cortex, and striatal patches, and along discrete axon tracts within the corpus callosum of the adult. We conclude that EphA5 function is not limited to the developing mouse brain and may play a role in synaptic plasticity in the adult.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.