ArticleEuropean biophysics journal : EBJ2010
Temperature dependence of fluctuations in HIV1-protease.
Article in European biophysics journal : EBJ, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Drug-resistant HIV-1 protease regains functional dynamics through cleavage site coevolution.Evolutionary applications · 2015Article
- Rationale for more diverse inhibitors in competition with substrates in HIV-1 protease.Biophysical journal · 2010Article
- BioPhysConnectoR: Connecting sequence information and biophysical models.BMC bioinformatics · 2010Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
Revealing the structure and the intrinsic dynamics of a protein is paramount to understand its function and other properties of evolutionary importance. Several schemes to obtain such insight in silico were developed over the decades. A computationally efficient protocol approximates the molecular dynamics around its native state by a harmonic potential. In this paper, we introduce a new methodology to combine the various harmonic approaches to understand the folding/unfolding dynamics and the dynamics around the native structure of the protein in a temperature dependent way. We apply this new protocol to the HIV1-protease and discuss the results in the light of events in the adaptive evolution towards drug resistance, which is a major problem in HIV infection.
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