ArticleInternational journal of molecular sciences2008
Specific siRNA targeting the receptor for advanced glycation end products inhibits experimental hepatic fibrosis in rats.
Article in International journal of molecular sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Preventive and Ameliorative Effects of Se- and Zn-Biofortified Chickpeas on MAFLD-Related Metabolic Disturbances.Foods (Basel, Switzerland) · 2026Article
- RAGE/SNAIL1 signaling drives epithelial-mesenchymal plasticity in metastatic triple-negative breast cancer.Oncogene · 2023Article
- RAGE Inhibitors in Neurodegenerative Diseases.Biomedicines · 2023Review
- A standardized pomegranate fruit extract ameliorates thioacetamide-induced liver fibrosis in rats via AGE-RAGE-ROS signaling.Heliyon · 2023Article
- Increased Expression of S100B and RAGE in a Mouse Model of Bile Duct Ligation-induced Liver Fibrosis.Journal of Korean medical science · 2021Article
- Ameliorative Effects of Nilotinib on CCl4 Induced Liver Fibrosis Via Attenuation of RAGE/HMGB1 Gene Expression and Oxidative Stress in Rat.Chonnam medical journal · 2017Article
- Article
- Small interfering RNA targeting receptor for advanced glycation end products suppresses the generation of proinflammatory cytokines.Experimental and therapeutic medicine · 2015Article
- Article
- The controversial role of retinoic acid in fibrotic diseases: analysis of involved signaling pathways.International journal of molecular sciences · 2012Review
- RAGE and tobacco smoke: insights into modeling chronic obstructive pulmonary disease.Frontiers in physiology · 2012Article
- Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches.Chemico-biological interactions · 2011Review
- The receptor for advanced glycation end products (RAGE) and the lung.Journal of biomedicine & biotechnology · 2010Review
- Role of the receptor for advanced glycation end products in hepatic fibrosis.World journal of gastroenterology · 2009Article
- The perplexing role of RAGE in pulmonary fibrosis: causality or casualty?Therapeutic advances in respiratory diseaseReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Receptor for advanced glycation end products (RAGE) was studied in different stages of carbon tetrachloride induced hepatic fibrosis (HF), and effect of its gene silencing in the HF development was evaluated in rats. Silencing RAGE expression by specific siRNA effectively suppressed NF-kappaB activity, hepatic stellate cell activation, and accumulation of extracellular matrix proteins in the fibrotic liver, and also greatly improved the histopathology and the ultrastructure of liver cells. These effects may be partially mediated by the inhibition on IkappaBalpha degradation. RAGE gene silencing effectively prevented liver from fibrosis, therefore it offers a potential pharmacological tool for anti-HF gene therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.