Evidence map›Paper›PMID 19325517›Full record

ArticleMolecules (Basel, Switzerland)2009

Chemical Composition and Antimicrobial Properties of Piper ovatum Vahl.

Daniel Rodrigues Silva, Eliana Harue Endo, Benedito Prado Dias Filho, Celso Vataru Nakamura, Terezinha Inez Estivaleti Svidzinski, Amanda de Souza, Maria Claudia M Young, Tânia Ueda-Nakamura, Diógenes Aparício Garcia Cortez

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Phytochemical and Pharmacological Insights intoMolecules (Basel, Switzerland) · 2025
    Review
  2. Article
  3. The Volatile Organic Compounds ofMicroorganisms · 2023
    Article
  4. Review
  5. Article
  6. Article
  7. Molecules (Basel, Switzerland) · 2019
    Review
  8. Article
  9. Article
  10. Article
  11. Early state research on antifungal natural products.Molecules (Basel, Switzerland) · 2014
    Review
  12. Article
  13. Article
  14. Antifungal activity of Piper diospyrifolium Kunth (Piperaceae) essential oil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2011
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniel Rodrigues SilvaPrograma de Pós-graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
Eliana Harue Endo
Benedito Prado Dias Filho
Celso Vataru Nakamura
Terezinha Inez Estivaleti Svidzinski
Amanda de Souza
Maria Claudia M Young
Tânia Ueda-Nakamura
Diógenes Aparício Garcia Cortez

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The chemical composition of the essential oil obtained from the leaves of Piperovatum Vahl by hydrodistillation was analyzed by GC-MS. The main constituents found were delta-amorphene (16.5 %), cis-muurola-4(14),5-diene (14.29 %) and gamma-muurolene(13.26%). The crude extracts and isolated compounds were screened for their antimicrobial activity. Hydroalcoholic extracts of different parts of Piper ovatum Vahl, essential oil andamides isolated from leaves were tested against Gram-positive and Gram-negative bacteria and Candida species. All extracts and amides were active against Bacillus subtilis andCandida tropicalis, including clinical strains. Essential oil was active against C. tropicalis.These amides showed an inhibitory effect on the adherence of C. tropicalis ATCC 28707 on cover glasses at 10 microg/mL, but did not show morphological alterations at the tested concentrations. Amides were identified as piperovatine and piperlonguminine, and showed MIC values of 15.6 and 31.2 microg/mL to B. subtilis and 3.9 microg/mL to C. tropicalis, and low toxic effects to Vero cells and macrophages.

Indexed as

AnimalsAnti-Infective AgentsCandidaChlorocebus aethiopsGas Chromatography-Mass SpectrometryGram-Negative BacteriaGram-Positive BacteriaHumansMacrophagesMicrobial Sensitivity TestsOils, VolatilePiperPlant ExtractsPlant LeavesVero CellsAnti-Infective AgentsOils, VolatilePlant Extracts

Identifiers

PMID19325517
PMCPMC6253832

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.