ArticleAmerican journal of respiratory and critical care medicine2009
Protection from lipopolysaccharide-induced lung injury by augmentation of airway S-nitrosothiols.
Article in American journal of respiratory and critical care medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. It is linked to trial NCT03926741 (Methods to Identify and Treat Severe Asthma Patients Project 1), which is not on this map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Methods to Identify and Treat Severe Asthma Patients Project 1: GSNOR Phenotyping and GSNO Challenge
Who cites it
27 citing papers in PubMed, 38 citations in OpenAlex.
- The rCC16 Protein Protects Against LPS-Induced Cell Apoptosis and Inflammatory Responses in Human Lung Pneumocytes.Frontiers in pharmacology · 2020Article
- Erratum: Protection from Lipopolysaccharide-induced Lung Injury by Augmentation of Airway S-NitrosothiolsAmerican journal of respiratory and critical care medicine · 2018Article
- How to Define Early Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2018Article
- Oridonin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-induced RAW264.7 cells and acute lung injury.Oncotarget · 2017Article
- LYRM03, an ubenimex derivative, attenuates LPS-induced acute lung injury in mice by suppressing the TLR4 signaling pathway.Acta pharmacologica Sinica · 2017Article
- Expression of Concern: Protection from Lipopolysaccharide-induced Lung Injury by Augmentation of Airway S-Nitrosothiols.American journal of respiratory and critical care medicine · 2016Article
- TXNIP/TRX/NF-κB and MAPK/NF-κB pathways involved in the cardiotoxicity induced by Venenum Bufonis in rats.Scientific reports · 2016Article
- Budesonide inhalation ameliorates endotoxin-induced lung injury in rabbits.Experimental biology and medicine (Maywood, N.J.) · 2015Article
- Anti-inflammatory and anti-apoptotic effects of oxysophoridine on lipopolysaccharide-induced acute lung injury in mice.American journal of translational research · 2015Article
- Thioredoxin-mediated denitrosylation regulates cytokine-induced nuclear factor κB (NF-κB) activation.The Journal of biological chemistry · 2014Article
- Simvastatin attenuates the lipopolysaccharideinduced inflammatory response of rat pulmonary microvascular endothelial cells by downregulating toll-like receptor 4 expression.Central European journal of medicine · 2014Article
- Solid-phase capture for the detection and relative quantification of S-nitrosoproteins by mass spectrometry.Methods (San Diego, Calif.) · 2013Review
- Repletion of S-nitrosohemoglobin improves organ function and physiological status in swine after brain death.Annals of surgery · 2013Article
- Diet-induced obesity reprograms the inflammatory response of the murine lung to inhaled endotoxin.Toxicology and applied pharmacology · 2013Article
- Nitrosothiols in the immune system: signaling and protection.Antioxidants & redox signaling · 2013Review
- Can nitric oxide-based therapy prevent bronchopulmonary dysplasia?Clinics in perinatology · 2012Review
- S-nitrosylation in the regulation of gene transcription.Biochimica et biophysica acta · 2012Article
- Protective role of T-bet and Th1 cytokines in pulmonary graft-versus-host disease and peribronchiolar fibrosis.American journal of respiratory cell and molecular biology · 2012Article
- S-nitrosoglutathione supplementation to ovalbumin-sensitized and -challenged mice ameliorates methacholine-induced bronchoconstriction.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- NOS2 regulation of LPS-induced airway inflammation via S-nitrosylation of NF-{kappa}B p65.American journal of physiology. Lung cellular and molecular physiology · 2011Article
Corrections and comments
- Expression of concern · 2016-06-01Concerns/Issues about Data · Investigation by Journal/Publisher · Unreliable Data · · Erin N Potts aka Erin N Potts-Kant;
- Commented on by
- Erratum issued
- Expression of concern
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
rationaleS-Nitrosothiols (SNO) inhibit immune activation of the respiratory epithelium and airway SNO levels are decreased in inflammatory lung disease. Ethyl nitrite (ENO) is a gas with chemical properties favoring SNO formation. Augmentation of airway SNO by inhaled ENO treatment may decrease lung inflammation and subsequent injury by inhibiting activation of the airway epithelium.
objectivesTo determine the effect of inhaled ENO on airway SNO levels and LPS-induced lung inflammation/injury.
methodsMice were treated overnight with inhaled ENO (10 ppm) or air, followed immediately by exposure to aerosolized LPS or saline. Parameters of inflammation and lung injury were quantified 1 hour after completion of the aerosol exposure and correlated to lung airway and tissue SNO levels. MEASUREMENTS AND MAIN
resultsAerosolized LPS induced a decrease in airway and lung tissue SNO levels including S-nitrosylated NF-kappaB. The decrease in lung SNO was associated with an increase in lung NF-kappaB activity, cytokine/chemokine expression (keratinocyte-derived chemokine, tumor necrosis factor-alpha, and IL-6), airway neutrophil influx, and worsened lung compliance. Pretreatment with inhaled ENO restored airway SNO levels and reduced LPS-mediated NF-kappaB activation thereby inhibiting the downstream inflammatory response and preserving lung compliance.
conclusionsAirway SNO serves an antiinflammatory role in the lung. Inhaled ENO can be used to augment airway SNO and protect from LPS-induced acute lung injury.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.