ArticleMolecular endocrinology (Baltimore, Md.)2009
The orphan nuclear receptor RORalpha restrains adipocyte differentiation through a reduction of C/EBPbeta activity and perilipin gene expression.
Article in Molecular endocrinology (Baltimore, Md.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- Quercetin and Fisetin activate circadian clock via RORα and inhibit adipocyte growth.bioRxiv : the preprint server for biology · 2026Article
- Clock Modulation by Naringenin Suppresses Lipogenesis and Promotes Adipose Tissue Browning.Journal of cellular physiology · 2026Article
- Retinoic acid-related orphan nuclear receptor alpha inhibits adipogenic differentiation of bone marrow mesenchymal stem cells via activating WNT/β-catenin signaling pathway.European journal of medical research · 2025Article
- Clock Modulation by Naringenin via RORα Suppresses Lipogenesis and Promotes Adipose Tissue Browning.bioRxiv : the preprint server for biology · 2025Article
- Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactions.Genome medicine · 2024Article
- The Circadian Nobiletin-ROR Axis Suppresses Adipogenic Differentiation and IκBα/NF-κB Signaling in Adipocytes.Nutrients · 2023Article
- Review
- The Clock-modulatory Activity of Nobiletin Suppresses Adipogenesis Via Wnt Signaling.Endocrinology · 2023Article
- A Degradable and Osteogenic Mg-Based MAO-MT-PLGA Drug/Ion Delivery System for Treating an Osteoporotic Fracture.Pharmaceutics · 2022Article
- RORα Regulates Odontoblastic Differentiation and Mediates the Pro-Odontogenic Effect of Melatonin on Dental Papilla Cells.Molecules (Basel, Switzerland) · 2021Article
- Pharmacological modulation of RORα controls fat browning, adaptive thermogenesis, and body weight in mice.American journal of physiology. Endocrinology and metabolism · 2021Article
- Article
- RXRα Positively Regulates Expression of the ChickenFrontiers in cell and developmental biology · 2020Article
- Retinoid-related orphan nuclear receptor alpha (RORα)-deficient mice display morphological testicular defects.Laboratory investigation; a journal of technical methods and pathology · 2019Article
- MicroRNA-10a-5p regulates macrophage polarization and promotes therapeutic adipose tissue remodeling.Molecular metabolism · 2019Article
- The nuclear retinoid-related orphan receptor RORα controls circadian thermogenic programming in white fat depots.Physiological reports · 2018Article
- RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network.Nature communications · 2017Article
- Identification of BCL11B as a regulator of adipogenesis.Scientific reports · 2016Article
- RORα switches transcriptional mode of ERRγ that results in transcriptional repression of CYP2E1 under ethanol-exposure.Nucleic acids research · 2016Article
- Perilipin2 plays a positive role in adipocytes during lipolysis by escaping proteasomal degradation.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nuclear receptor-type transcription factor retinoic acid receptor-related orphan receptor alpha (RORalpha) is a multifunctional molecule involved in tissue development and cellular function, such as inflammation, metabolism, and differentiation; however, the role of RORalpha during adipocyte differentiation has not yet been fully understood. Here we show that RORalpha inhibits the transcriptional activity of CCAAT/enhancer-binding protein beta (C/EBPbeta) without affecting its expression, thereby blocking the induction of both PPARgamma and C/EBPalpha, resulting in the suppression of C/EBPbeta-dependent adipogenesis. RORalpha interacted with C/EBPbeta so as to repress both the C/EBPbeta-p300 association and the C/EBPbeta-dependent recruitment of p300 to chromatin. In addition to the inhibitory effect on C/EBPbeta function, RORalpha also prevents the expression of the lipid droplet coating protein gene perilipin by peroxisome proliferators-activated receptor gamma (PPARgamma), acting through the specific mechanism of its promoter. We identified a suppressive ROR-responsive element overlapping the PPAR-responsive element in the perilipin promoter and verified that RORalpha competitively antagonizes the binding of PPARgamma. RORalpha inhibits PPARgamma-dependent adipogenesis along with the repression of perilipin induction. These findings suggest that RORalpha is a novel negative regulator of adipocyte differentiation that acts through dual mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.