ArticleHuman molecular genetics2009
Large-scale analysis of exonized mammalian-wide interspersed repeats in primate genomes.
Article in Human molecular genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- A recent and rapid genome expansion driven by the amplification of transposable elements in the Neotropical annual killifish Garcialebias charrua.Biological research · 2025Article
- Reactivation of retrotransposable elements is associated with environmental stress and ageing.Nature reviews. Genetics · 2025Review
- Alu insertion-mediated dsRNA structure formation with pre-existing Alu elements as a disease-causing mechanism.American journal of human genetics · 2024Article
- Evidence for a novel overlapping coding sequence in POLG initiated at a CUG start codon.BMC genetics · 2020Article
- A tissue-specific promoter derived from a SINE retrotransposon drives biallelic expression of PLAGL1 in human lymphocytes.PloS one · 2017Article
- The domain structure and distribution of Alu elements in long noncoding RNAs and mRNAs.RNA (New York, N.Y.) · 2016Article
- Evolutionary impact of transposable elements on genomic diversity and lineage-specific innovation in vertebrates.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Review
- The Recent De Novo Origin of Protein C-Termini.Genome biology and evolution · 2015Article
- Species-specific exon loss in human transcriptomes.Molecular biology and evolution · 2015Article
- Reverse transcriptase and intron number evolution.Stem cell investigation · 2014Article
- Article
- Transposable elements reveal a stem cell-specific class of long noncoding RNAs.Genome biology · 2012Article
- Male germline control of transposable elements.Biology of reproduction · 2012Review
- Alu elements: know the SINEs.Genome biology · 2011Review
- Human genetics and genomics a decade after the release of the draft sequence of the human genome.Human genomics · 2011Review
- Extracellular inhibitors, repellents, and semaphorin/plexin/MICAL-mediated actin filament disassembly.Cytoskeleton (Hoboken, N.J.) · 2011Review
- The struggle for life of the genome's selfish architects.Biology direct · 2011Review
- Putatively noncoding transcripts show extensive association with ribosomes.Genome biology and evolution · 2011Article
- All y'all need to know 'bout retroelements in cancer.Seminars in cancer biology · 2010Review
- Evolution of alternative splicing in primate brain transcriptomes.Human molecular genetics · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Transposable elements (TEs) are major sources of new exons in higher eukaryotes. Almost half of the human genome is derived from TEs, and many types of TEs have the potential to exonize. In this work, we conducted a large-scale analysis of human exons derived from mammalian-wide interspersed repeats (MIRs), a class of old TEs which was active prior to the radiation of placental mammals. Using exon array data of 328 MIR-derived exons and RT-PCR analysis of 39 exons in 10 tissues, we identified 15 constitutively spliced MIR exons, and 15 MIR exons with tissue-specific shift in splicing patterns. Analysis of RNAs from multiple species suggests that the splicing events of many strongly included MIR exons have been established before the divergence of primates and rodents, while a small percentage result from recent exonization during primate evolution. Interestingly, exon array data suggest substantially higher splicing activities of MIR exons when compared with exons derived from Alu elements, a class of primate-specific retrotransposons. This appears to be a universal difference between exons derived from young and old TEs, as it is also observed when comparing Alu exons to exons derived from LINE1 and LINE2, two other groups of old TEs. Together, this study significantly expands current knowledge about exonization of TEs. Our data imply that with sufficient evolutionary time, numerous new exons could evolve beyond the evolutionary intermediate state and contribute functional novelties to modern mammalian genomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.