ArticleProceedings. Biological sciences2009
Foam nest components of the túngara frog: a cocktail of proteins conferring physical and biological resilience.
Article in Proceedings. Biological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 89 citations in OpenAlex.
- Courtship at reaching-range in the túngara frog.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- Genomic and Transcriptomic Insights into the Genetic Basis of Foam Secretion in Rice SpittlebugInternational journal of molecular sciences · 2024Article
- Foam fractionation Tags (F-Tags) enabling surfactant-free, activity-preserving recovery of enzymes.Applied microbiology and biotechnology · 2024Article
- Adhesive properties of Aphrophoridae spittlebug foam.Journal of the Royal Society, Interface · 2024Article
- Article
- Form, function, foam: evolutionary ecology of anuran nests and nesting behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Neotropical Frog Foam Nest's Microbiomes.Microorganisms · 2023Article
- Early life skin microbial trajectory as a function of vertical and environmental transmission in Bornean foam-nesting frogs.Animal microbiome · 2021Article
- Frog nest foams exhibit pharmaceutical foam-like properties.Royal Society open science · 2021Article
- Developments in Amphibian Parental Care Research: History, Present Advances, and Future Perspectives.Herpetological monograph · 2020Article
- Transcriptomic analysis of differentially expressed genes in the oviduct of Rhacophorus omeimontis provides insights into foam nest construction.BMC genomics · 2019Article
- Defences against brood parasites from a social immunity perspective.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Spittlebugs produce foam as a thermoregulatory adaptation.Scientific reports · 2018Article
- Egg perivitelline fluid of the invasive snailPeerJ · 2018Article
- Frog foams and natural protein surfactants.Colloids and surfaces. A, Physicochemical and engineering aspects · 2017Article
- Convergent evolution of plant and animal embryo defences by hyperstable non-digestible storage proteins.Scientific reports · 2017Article
- Profiling of adhesive-related genes in the freshwater cnidarian Hydra magnipapillata by transcriptomics and proteomics.Biofouling · 2016Article
- The Conformation of Interfacially Adsorbed Ranaspumin-2 Is an Arrested State on the Unfolding Pathway.Biophysical journal · 2016Article
- The Diverse Structures and Functions of Surfactant Proteins.Trends in biochemical sciences · 2016Review
- Resonance assignments for latherin, a natural surfactant protein from horse sweat.Biomolecular NMR assignments · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The foam nests of the túngara frog (Engystomops pustulosus) form a biocompatible incubation medium for eggs and sperm while resisting considerable environmental and microbiological assault. We have shown that much of this behaviour can be attributed to a cocktail of six proteins, designated ranaspumins (Rsn-1 to Rsn-6), which predominate in the foam. These fall into two discernable classes based on sequence analysis and biophysical properties. Rsn-2, with an amphiphilic amino acid sequence unlike any hitherto reported, exhibits substantial detergent-like surfactant activity necessary for production of foam, yet is harmless to the membranes of eggs and spermatozoa. A further four (Rsn-3 to Rsn-6) are lectins, three of which are similar to fucolectins found in teleosts but not previously identified in a land vertebrate, though with a carbohydrate binding specificity different from previously described fucolectins. The sixth, Rsn-1, is structurally similar to proteinase inhibitors of the cystatin class, but does not itself appear to exhibit any such activity. The nest foam itself, however, does exhibit potent cystatin activity. Rsn-encoding genes are transcribed in many tissues of the adult frogs, but the full cocktail is present only in oviduct glands. Combinations of lectins and cystatins have known roles in plants and animals for defence against microbial colonization and insect attack. Túngara nest foam displays a novel synergy of selected elements of innate defence plus a specialized surfactant protein, comprising a previously unreported strategy for protection of unattended reproductive stages of animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.