Evidence map›Paper›PMID 19324675›Full record

ReviewJournal of the Royal Society, Interface2009

Harnessing nature's toolbox: regulatory elements for synthetic biology.

Patrick M Boyle, Pamela A Silver

Abstract readReview
In one paragraph

Review in Journal of the Royal Society, Interface, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Model-Based Design of Biochemical Microreactors.Frontiers in bioengineering and biotechnology · 2016
    Article
  6. Intramolecular arrangement of sensor and regulator overcomes relaxed specificity in hybrid two-component systems.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
  7. Review
  8. Modularity of a carbon-fixing protein organelle.Proceedings of the National Academy of Sciences of the United States of America · 2012
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Synthetic biology: history, challenges and prospects.Journal of the Royal Society, Interface · 2009
    Article
  15. Opportunities for microfluidic technologies in synthetic biology.Journal of the Royal Society, Interface · 2009
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Patrick M BoyleDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Pamela A Silver

Funding

Molecular, Cellular, & Developmental Dynamics PhD ProgramT32GM007226 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI VAN VACTOR, DAVID L. · 1985 to 2021
$14.4M
NIGMS NIH HHS T32 GM007226
6 · The paper itself

Abstract

Synthetic biologists seek to engineer complex biological systems composed of modular elements. Achieving higher complexity in engineered biological organisms will require manipulating numerous systems of biological regulation: transcription; RNA interactions; protein signalling; and metabolic fluxes, among others. Exploiting the natural modularity at each level of biological regulation will promote the development of standardized tools for designing biological systems.

Indexed as

AnimalsBiotechnologyComputational BiologyGenetic EngineeringHumansModels, BiologicalNanotechnologyNucleic Acid ConformationProtein EngineeringProteinsRNASignal Processing, Computer-AssistedSystems BiologyTranscription, GeneticProteinsRNA

Identifiers

PMID19324675
PMCPMC2843961

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.