ArticleThe Journal of pediatrics2009
Cerebral blood flow velocities in extremely low birth weight infants with hypotension and infants with normal blood pressure.
Article in The Journal of pediatrics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Hemodynamic effects of delayed cord clamping in premature infants.Pediatrics · 2012Trial
- Pathogenesis and Prevention of Intraventricular Hemorrhage in Preterm Infants.Journal of Korean Neurosurgical Society · 2023Article
- Association of early cerebral oxygen saturation and brain injury in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Sodium supply from administered blood products was associated with severe intraventricular haemorrhage in extremely preterm infants.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Cerebral Hemodynamics Are Not Affected by the Size of the Patent Ductus Arteriosus.Neonatology · 2020Article
- Neuroprotection from acute brain injury in preterm infants.Paediatrics & child health · 2019Review
- Neonatal cerebrovascular autoregulation.Pediatric research · 2018Review
- Elevated Diastolic Closing Margin Is Associated with Intraventricular Hemorrhage in Premature Infants.The Journal of pediatrics · 2016Article
- Ontogeny of cerebrovascular critical closing pressure.Pediatric research · 2015Article
- The ontogeny of cerebrovascular pressure autoregulation in premature infants.Journal of perinatology : official journal of the California Perinatal Association · 2014Article
- Pathogenesis and prevention of intraventricular hemorrhage.Clinics in perinatology · 2014Review
- Observational study of cerebral hemodynamics during dopamine treatment in hypotensive ELBW infants on the first day of life.Journal of perinatology : official journal of the California Perinatal Association · 2013Observational
- Early postnatal hypotension and developmental delay at 24 months of age among extremely low gestational age newborns.Archives of disease in childhood. Fetal and neonatal edition · 2011Article
Corrections and comments
- Commented on by
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine whether extremely low birth weight (ELBW) infants with hypotension have similar cerebral hemodynamics when compared with control subjects with normal blood pressure. We hypothesized that ELBW infants with low or normal blood pressure have similar cerebral blood flow (CBF) velocity. STUDY
designIn this case control study, CBF velocity (with Doppler ultrasound scanning), PCO2, and mean arterial blood pressure (MABP) were continuously monitored twice daily before intensive care procedures. If an infant became hypotensive (MABP < or = gestational age in weeks), additional monitoring was performed for 10 to 20 minutes, before treatment with dopamine. Thirty ELBW infants were enrolled (637 +/- 140 g, 24.2 +/- 1.1 weeks); 15 had hypotension, and 15 were gestational age/birth weight-matched control subjects with normal blood pressure. CBF velocity was compared by use of the Mann-Whitney U test.
resultsThe groups did not differ significantly in gestational age, birth weight, race, sex, PCO2, Apgar scores, or occurrence of severe intraventricular hemorrhage. There was no difference in mean CBF velocity (P = .934) in infants with hypotension (MABP: 23 [20-24.9] mm Hg) compared with infants with normal blood pressure (MABP: 32.6 [27.5-35.7] mm Hg).
conclusionDespite having hypotension, ELBW infants (before treatment) had similar CBF velocity compared with control subjects with normal blood pressure. On the basis of these results, hypotension may not indicate decreased CBF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.