ArticleHeart rhythm2009
Atrial cellular electrophysiological changes in patients with ventricular dysfunction may predispose to AF.
Article in Heart rhythm, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Failure of intravenous nifekalant cardioversion as an independent predictor for persistent atrial fibrillation recurrence after catheter ablation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Article
- Arrhythmogenic Remodeling in the Failing Heart.Cells · 2021Review
- Heart failure-induced atrial remodelling promotes electrical and conduction alternans.PLoS computational biology · 2020Article
- Triggered CaCirculation. Arrhythmia and electrophysiology · 2020Article
- Calcium in the Pathophysiology of Atrial Fibrillation and Heart Failure.Frontiers in physiology · 2018Review
- Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation.Frontiers in physiology · 2018Article
- Atrial Fibrillation in Heart Failure: a Therapeutic Challenge of Our Times.Korean circulation journal · 2017Review
- The Stress-Response MAP Kinase Signaling in Cardiac Arrhythmias.Reviews of physiology, biochemistry and pharmacology · 2016Review
- Atrial Electrophysiological Remodeling and Fibrillation in Heart Failure.Clinical Medicine Insights. Cardiology · 2016Review
- Effectiveness of aldosterone antagonists for preventing atrial fibrillation after cardiac surgery in patients with systolic heart failure: a retrospective study.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Article
- SR calcium handling dysfunction, stress-response signaling pathways, and atrial fibrillation.Frontiers in physiology · 2015Review
- Calcium-activated potassium current modulates ventricular repolarization in chronic heart failure.PloS one · 2014Article
- Pro-arrhythmogenic effects of atrial fibrillation-induced electrical remodelling: insights from the three-dimensional virtual human atria.The Journal of physiology · 2013Article
- Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarizations, and fibrillation.Cardiovascular research · 2013Article
- Differential effects of the peroxynitrite donor, SIN-1, on atrial and ventricular myocyte electrophysiology.Journal of cardiovascular pharmacology · 2013Article
- Transient outward K+ current reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes.The Journal of physiology · 2012Article
- Mechanisms of termination and prevention of atrial fibrillation by drug therapy.Pharmacology & therapeutics · 2011Review
- Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology.Cardiovascular research · 2011Article
- Rhythm control strategies and the role of antiarrhythmic drugs in the management of atrial fibrillation: focus on clinical outcomes.Journal of general internal medicine · 2011Review
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8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundLeft ventricular systolic dysfunction (LVSD) is a risk factor for atrial fibrillation (AF), but the atrial cellular electrophysiological mechanisms in humans are unclear.
objectiveThis study sought to investigate whether LVSD in patients who are in sinus rhythm (SR) is associated with atrial cellular electrophysiological changes that could predispose to AF.
methodsRight atrial myocytes were obtained from 214 consenting patients in SR who were undergoing cardiac surgery. Action potentials or ion currents were measured using the whole-cell-patch clamp technique.
resultsThe presence of moderate or severe LVSD was associated with a shortened atrial cellular effective refractory period (ERP) (209 +/- 8 ms; 52 cells, 18 patients vs 233 +/- 7 ms; 134 cells, 49 patients; P <0.05); confirmed by multiple linear regression analysis. The left ventricular ejection fraction (LVEF) was markedly lower in patients with moderate or severe LVSD (36% +/- 4%, n = 15) than in those without LVSD (62% +/- 2%, n = 31; P <0.05). In cells from patients with LVEF <or= 45%, the ERP and action potential duration at 90% repolarization were shorter than in those from patients with LVEF > 45%, by 24% and 18%, respectively. The LVEF and ERP were positively correlated (r = 0.65, P <0.05). The L-type calcium ion current, inward rectifier potassium ion current, and sustained outward ion current were unaffected by LVSD. The transient outward potassium ion current was decreased by 34%, with a positive shift in its activation voltage, and no change in its decay kinetics.
conclusionLVSD in patients in SR is independently associated with a shortening of the atrial cellular ERP, which may be expected to contribute to a predisposition to AF.
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