ArticleNeuron2009
Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor.
Article in Neuron, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 70 citations in OpenAlex.
- Presynaptic control of top-down signaling in neocortical layer 1.bioRxiv : the preprint server for biology · 2026Article
- Inhibition of BK channels by GABAb receptors enhances intrinsic excitability of layer 2/3 vasoactive intestinal polypeptide-expressing interneurons in mouse neocortex.The Journal of physiology · 2025Article
- A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Input associativity underlies fear memory renewal.National science review · 2021Article
- Axo-axonic synapses: Diversity in neural circuit function.The Journal of comparative neurology · 2021Review
- Role of the GABAPsychopharmacology · 2020Article
- Role of lateral amygdala calstabin2 in regulation of fear memory.Molecular brain · 2020Article
- Chronic Stress Oppositely Regulates Tonic Inhibition in Thy1-Expressing and Non-expressing Neurons in Amygdala.Frontiers in neuroscience · 2020Article
- Impact of Chronic BDNF Depletion on GABAergic Synaptic Transmission in the Lateral Amygdala.International journal of molecular sciences · 2019Article
- Baclofen acts in the central amygdala to reduce synaptic transmission and impair context fear conditioning.Scientific reports · 2018Article
- Comparing the Antiseizure and Neuroprotective Efficacy of LY293558, Diazepam, Caramiphen, and LY293558-Caramiphen Combination against Soman in a Rat Model Relevant to the Pediatric Population.The Journal of pharmacology and experimental therapeutics · 2018Article
- Sucrose-induced plasticity in the basolateral amygdala in a 'comfort' feeding paradigm.Brain structure & function · 2017Article
- δ Subunit-containing GABALearning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Lateral Orbitofrontal Cortical Modulation on the Medial Prefrontal Cortex-Amygdala Pathway: Differential Regulation of Intra-Amygdala GABAA and GABAB Receptors.The international journal of neuropsychopharmacology · 2017Article
- GABAPhysiological reports · 2017Article
- The basolateral amygdala γ-aminobutyric acidergic system in health and disease.Journal of neuroscience research · 2016Review
- Postnatal maturation of GABAergic modulation of sensory inputs onto lateral amygdala principal neurons.The Journal of physiology · 2015Article
- Identifying the role of pre-and postsynaptic GABA(B) receptors in behavior.Neuroscience and biobehavioral reviews · 2015Review
- Hippocampal Theta Input to the Amygdala Shapes Feedforward Inhibition to Gate Heterosynaptic Plasticity.Neuron · 2015Article
- Neocortical somatostatin neurons reversibly silence excitatory transmission via GABAb receptors.Current biology : CB · 2015Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
GABAb receptor (GABAbR)-mediated suppression of glutamate release is critical for limiting glutamatergic transmission across the central nervous system (CNS). Here we show that, upon tetanic stimulation of afferents to lateral amygdala, presynaptic GABAbR-mediated inhibition only occurs in glutamatergic inputs to principle neurons (PNs), not to interneurons (INs), despite the presence of GABAbR in terminals to both types of neurons. The selectivity is caused by differential local GABA accumulation; it requires GABA reuptake and parallels distinct spatial distributions of presynaptic GABAbR in terminals to PNs and INs. Moreover, GABAbR-mediated suppression of theta-burst-induced long-term potentiation (LTP) occurs only in the inputs to PNs, not to INs. Thus, target-cell-specific control of glutamate release by presynaptic GABAbR orchestrates the inhibitory dominance inside amygdala and might contribute to prevention of nonadaptive defensive behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.