Evidence map›Paper›PMID 19323975›Full record

ReviewMicrovascular research2009

The pericyte: cellular regulator of microvascular blood flow.

Matthew E Kutcher, Ira M Herman

Abstract readReview
In one paragraph

Review in Microvascular research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 159 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Angiogenesis in Wound Repair: Too Much of a Good Thing?Cold Spring Harbor perspectives in biology · 2022
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Three-DimensionalFrontiers in toxicology · 2021
    Review
  16. Article
  17. Characterization of Burn Eschar Pericytes.Journal of clinical medicine · 2020
    Article
  18. Review
  19. Article
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Matthew E KutcherDepartment of Physiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
Ira M Herman
Tufts University · US

Funding

Regulating retinal microvascular morphogenesisR01EY015125 · NEI · TUFTS UNIVERSITY BOSTON · PI HERMAN, IRA M · 2004 to 2010
$1.7M
RETINAL MICROVASCULAR CELLS, MATRIX, &OCULAR DISORDERSR01EY009033 · NEI · TUFTS UNIVERSITY BOSTON · PI HERMAN, IRA M · 1993 to 2002
$817k
NEI NIH HHS EY 15125NEI NIH HHS R01 EY009033NEI NIH HHS R01 EY015125
6 · The paper itself

Abstract

The vascular system - through its development, response to injury, and remodeling during disease - constitutes one of the key organ systems sustaining normal human physiology; conversely, its dysregulation also underlies multiple pathophysiologic processes. Regulation of vascular endothelial cell function requires the integration of complex signals via multiple cell types, including arterial smooth muscle, capillary and post-capillary pericytes, and other perivascular cells such as glial and immune cells. Here, we focus on the pericyte and its roles in microvascular remodeling, reviewing current concepts in microvascular pathophysiology and offering new insights into the specific roles that pericyte-dependent signaling pathways may play in modulating endothelial growth and microvascular tone during pathologic angiogenesis and essential hypertension.

Indexed as

PericytesGTPase-Activating ProteinsHumansHypertensionMicrovesselsMuscle, Smooth, VascularNeovascularization, PathologicRegional Blood FlowSignal TransductionGTPase-Activating Proteins

Identifiers

PMID19323975
PMCPMC2668721
OpenAlexW1984998073

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.