ArticleMicrovascular research2009
Effects of erythrocyte deformability and aggregation on the cell free layer and apparent viscosity of microscopic blood flows.
Article in Microvascular research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 208 citations in OpenAlex.
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- Placental iron utilisation in fetal growth restriction: alterations in mitochondrial haem synthesis and iron-sulphur cluster assembly pathways.The Journal of physiology · 2026Article
- Quantifying the unique mechanical properties of irreversibly sickled cells in sickle cell disease.Blood vessels, thrombosis & hemostasis · 2025Article
- Image-based flow simulation of platelet aggregates under different shear rates.PLoS computational biology · 2023Article
- Lingering Dynamics of Type 2 Diabetes Mellitus Red Blood Cells in Retinal Arteriolar Bifurcations.Journal of functional biomaterials · 2022Article
- A mechanistic model of cross-bridge migration in RBC aggregation and disaggregation.Frontiers in bioengineering and biotechnology · 2022Article
- Advanced Constitutive Modeling of the Thixotropic Elasto-Visco-Plastic Behavior of Blood: Steady-State Blood Flow in Microtubes.Materials (Basel, Switzerland) · 2021Article
- Examining metastatic behavior within 3D bioprinted vasculature for the validation of a 3D computational flow model.Science advances · 2020Article
- Endothelial Cell Targeting by cRGD-Functionalized Polymeric Nanoparticles under Static and Flow Conditions.Nanomaterials (Basel, Switzerland) · 2020Article
- Spatial and temporal patterns of nitric oxide diffusion and degradation drive emergent cerebrovascular dynamics.PLoS computational biology · 2020Article
- Shear-induced non-monotonic viscosity dependence for model red blood cell suspensions in microvessels.Biomicrofluidics · 2019Article
- A portable rotating disc as blood rheometer.Biomicrofluidics · 2019Article
- Microfluidic-Based Biosensor for Sequential Measurement of Blood Pressure and RBC Aggregation Over Continuously Varying Blood Flows.Micromachines · 2019Article
- Estimation of membrane bending modulus of stiffness tuned human red blood cells from micropore filtration studies.PloS one · 2019Article
- Extended photoacoustic transport model for characterization of red blood cell morphology in microchannel flow.Biomedical optics express · 2018Article
- Echocardiography Differentiates Lethally Irradiated Whole-Body From Partial-Body Exposed Rats.Frontiers in cardiovascular medicine · 2018Article
- Implications Enzymatic Degradation of the Endothelial Glycocalyx on the Microvascular Hemodynamics and the Arteriolar Red Cell Free Layer of the Rat Cremaster Muscle.Frontiers in physiology · 2018Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Concentrated erythrocyte (i.e., red blood cell) suspensions flowing in microchannels have been simulated with an immersed-boundary lattice Boltzmann algorithm, to examine the cell layer development process and the effects of cell deformability and aggregation on hemodynamic and hemorheological behaviors. The cells are modeled as two-dimensional deformable biconcave capsules and experimentally measured cell properties have been utilized. The aggregation among cells is modeled by a Morse potential. The flow development process demonstrates how red blood cells migrate away from the boundary toward the channel center, while the suspending plasma fluid is displaced to the cell free layer regions left by the migrating cells. Several important characteristics of microscopic blood flows observed experimentally have been well reproduced in our model, including the cell free layer, blunt velocity profile, changes in apparent viscosity, and the Fahraeus effect. We found that the cell free layer thickness increases with both cell deformability and aggregation strength. Due to the opposing effects of the cell free layer lubrication and the high viscosity of cell-concentrated core, the influence of aggregation is complex but the lubrication effect appears to dominate, causing the relative apparent viscosity to decrease with aggregation. It appears therefore that the immersed-boundary lattice Boltzmann numerical model may be useful in providing valuable information on microscopic blood flows in various microcirculation situations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.