ArticleBMC cancer2009
Microvessel density as new prognostic marker after radiotherapy in rectal cancer.
Article in BMC cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Can vascular endothelial growth factor and microvessel density be used as prognostic biomarkers for colorectal cancer? A systematic review and meta-analysis.TheScientificWorldJournal · 2014Pooled it
- Tissue Microvessel Density as a Potential Predictive Marker for Vascular Invasion in Colorectal Cancer.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Article
- Pretreatment Microvessel Density for Predicting of Tumor Responsiveness to Neoadjuvant Chemoradiotherapy of Locally Advanced Rectal Cancer.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Dual effects of radiotherapy on tumor microenvironment and its contribution towards the development of resistance to immunotherapy in gastrointestinal and thoracic cancers.Frontiers in cell and developmental biology · 2023Review
- Evaluation of the Metabolic Activity of the Infiltration and Proliferation Areas of Hepatic Alveolar Echinococcosis in Rats Using Contrast-Enhanced Ultrasound.The American journal of tropical medicine and hygiene · 2022Article
- Human papillomavirus (HPV) 16 infection is not detected in rectal carcinoma.Infectious agents and cancer · 2020Article
- Correlation between vascular endothelial growth factor-A expression and tumor location and invasion in patients with colorectal cancer.Journal of gastrointestinal oncology · 2018Article
- Recurrences in stage II rectal carcinoma after curative resection alone: from the viewpoint of angiogenesis.World journal of surgical oncology · 2016Article
- Article
- Overexpressions of DLL4 and CD105 are Associated with Poor Prognosis of Patients with Pancreatic Ductal Adenocarcinoma.Pathology oncology research : POR · 2015Article
- Prognostic Significance of Microvessel Density Determining by Endoglin in Stage II Rectal Carcinoma: A Retrospective Analysis.Gastroenterology research and practice · 2015Article
- Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival.BioMed research international · 2015Article
- Article
- Quantitative perfusion- and diffusion-weighted magnetic resonance imaging of gastrointestinal cancers treated with multikinase inhibitors: a pilot study.Gastrointestinal cancer research : GCR · 2014Article
- Effect of different rhBMP-2 and TG-VEGF ratios on the formation of heterotopic bone and neovessels.BioMed research international · 2014Article
- High microvessel density in pancreatic ductal adenocarcinoma is associated with high grade.Virchows Archiv : an international journal of pathology · 2013Article
- Characterization of the melanoma brain metastatic niche in mice and humans.Cancer medicine · 2013Article
- Microvessel density and heparanase over-expression in clear cell renal cell cancer: correlations and prognostic significances.World journal of surgical oncology · 2011Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe extent of angiogenesis is an important prognostic factor for colorectal carcinoma, however, there are few studies concerning changes in angiogenesis with radiotherapy (RTX). Our aim was to investigate changes in tumor angiogenesis influenced by radiotherapy to assess the prognostic value of angiogenesis the microvessel density (MVD) in overall survival after radiotherapy.
methodsTumor specimens were taken from 101 patients resected for rectal cancer. The patients were divided into three groups according to the treatment they received before surgery (not treated, a short course, or long course of RTX). Tumor specimens were paraffin-embedded and immunohistochemistry was performed with primary antibody against CD-34 to count MVD.
resultsMVD was significantly lower in the group of patients treated with a long course of RTX (p <0.025). The mean MVD for the long RTX group was 134.8; for the short RTX group - 192.5; and for those not treated with RTX - 193.0. There were no significant statistical correlations between MVD and age, sex, grade of tumor differentiation (G) and tumor size (T) in those untreated with RTX. In long RTX group we found a significant prognostic rate for MVD when the density cut off was near 130 with 92.3% sensitivity and 64.7% specificity. When the MVD was lower than a cut off of 130, the survival period significantly increased (p = 0.001), the mortality rate is significantly higher if the MVD is higher than 130 (microvessel/mm2) (1953.047; p = 0.002), if the histological grade is moderate/poor (127.407; p = 0.013), if the tumor is T3/T4 (111.618; p = 0.014), and if the patient is male (17.92; p = 0.034) adjusted by other variable in model.
conclusionOur results show that a long course of radiotherapy significantly decreased angiogenesis in rectal cancer tissue. MVD was found to be a favourable marker for tumor behaviour during RTX and a predictor of overall survival after long course of RTX. Further investigations are now needed to determine the changes in angiogenesis during a shorter course of RTX.
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