ArticleBMC medical genetics2009
Knowledge about hereditary nonpolyposis colorectal cancer; mutation carriers and physicians at equal levels.
Article in BMC medical genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Uptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for Lynch syndrome.Scientific reports · 2020Article
- How does genetic risk information for Lynch syndrome translate to risk management behaviours?Hereditary cancer in clinical practice · 2017Article
- How, who, and when: preferences for delivery of genome sequencing results among women diagnosed with breast cancer at a young age.Molecular genetics & genomic medicine · 2016Article
- A systematic approach to the reporting of medically relevant findings from whole genome sequencing.BMC medical genetics · 2014Article
- Development of an integrated support system for hereditary cancer and its impact on gynecologic services.International journal of clinical oncology · 2014Article
- The evolution of colorectal cancer genetics-Part 1: from discovery to practice.Journal of gastrointestinal oncology · 2014Review
- Knowledge, attitudes and referral patterns of lynch syndrome: a survey of clinicians in australia.Journal of personalized medicine · 2014Article
- Communication of genetic test results to family and health-care providers following disclosure of research results.Genetics in medicine : official journal of the American College of Medical Genetics · 2014Article
- Barriers and motivators for referral of patients with suspected lynch syndrome to cancer genetic services: a qualitative study.Journal of personalized medicine · 2014Article
- Perceived versus predicted risks of colorectal cancer and self-reported colonoscopies by members of mismatch repair gene mutation-carrying families who have declined genetic testing.Journal of genetic counseling · 2014Article
- 100 years Lynch syndrome: what have we learned about psychosocial issues?Familial cancer · 2013Review
- Acceptance of genetic counseling and testing in a hospital-based series of patients with gynecological cancer.Journal of genetic counseling · 2013Article
- Genetic testing and cancer risk management recommendations by physicians for at-risk relatives.Genetics in medicine : official journal of the American College of Medical Genetics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIdentification and adequate management of individuals at risk for hereditary nonpolyposis colorectal cancer (HNPCC) is crucial since surveillance programmes reduce morbidity and mortality. We investigated knowledge about key features of HNPCC in at risk individuals and physicians in surgery, gynecology and oncology.
methodsData were collected using a questionnaire which was answered by 67 mutation carriers and 102 physicians from the southern Swedish health care region. The statements were related to colorectal cancer, heredity and surveillance and the physicians were also asked questions about cancer risks and surveillance strategies.
resultsBoth groups answered questions on colorectal cancer risk, surveillance and genetic testing well, whereas answers about inheritance and risks for HNPCC associated cancer were less accurate. Only half of the family members and one third of the physicians correctly estimated the risk to inherit an HNPCC predisposing mutation. Among family members, young age (<57 years), female sex and recent genetic counseling significantly correlated with better results. Physicians generally underestimated the risk of HNPCC associated cancers and three out of four suggested a later starting age for surveillance than recommended.
conclusionThe finding of similar levels of knowledge about key features of HNPCC in at risk individuals and physicians reflect the challenge physicians face in keeping up to date on hereditary cancer and may have implications for the clinical management and professional relations with HNPCC family members.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.