ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2009
Prospective case-control study of the association between common enteric protozoal parasites and diarrhea in Bangladesh.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 3 of them syntheses that pooled it.
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Who cites it
79 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Worldwide prevalence of protozoans and helminths among disabled people: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Systematic Review on the Correlation of Quantitative PCR Cycle Threshold Values of Gastrointestinal Pathogens With Patient Clinical Presentation and Outcomes.Frontiers in medicine · 2021Pooled it
- A systematic review and meta-analysis of the association between Giardia lamblia and endemic pediatric diarrhea in developing countries.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012Pooled it
- Effect of Nitazoxanide and Probiotic Treatment on Bangladeshi Children with Cryptosporidiosis.The American journal of tropical medicine and hygiene · 2025Trial
- Trial
- Protection against diarrhea associated with Giardia intestinalis Is lost with multi-nutrient supplementation: a study in Tanzanian children.PLoS neglected tropical diseases · 2011Trial
- Targeted CRISPR screens reveal genes essential for Cryptosporidium survival in the host intestine.Nature communications · 2025Article
- Occurrence and assemblage distribution of Giardia Duodenalis in symptomatic and asymptomatic patients in southeastern Iran (2019-2022).Gut pathogens · 2024Article
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- Correlation between Melatonin and Colostral Regulatory T Cells inBiomolecules · 2024Article
- Molecular characterization and zoonotic risk assessment ofOne health (Amsterdam, Netherlands) · 2024Article
- Microscopy detection and molecular characterisation ofFrontiers in public health · 2024Article
- Childhood Intestinal Parasitic Reinfection, Sanitation and Hygiene Practice in Eastern Ethiopia: Case Control Study.Infection and drug resistance · 2024Article
- Prevalence and assemblage of Giardia duodenalis in a case-control study of children under 5 years from Jimma, Southwest Ethiopia.Parasitology research · 2023Article
- Genomic Heterogeneity of Cryptosporidium parvum Isolates From Children in Bangladesh: Implications for Parasite Biology and Human Infection.The Journal of infectious diseases · 2023Article
- Specific Cryptosporidium antigens associate with reinfection immunity and protection from cryptosporidiosis.The Journal of clinical investigation · 2023Article
- High Diversity ofTropical medicine and infectious disease · 2023Article
- Etiology of Acute Diarrheal Disease and Antimicrobial Susceptibility Pattern in Children Younger Than 5 Years Old in Nepal.The American journal of tropical medicine and hygiene · 2023Article
- Potential Zoonotic Transmission ofTransboundary and emerging diseases · 2023Article
- Uncovering the genetic diversity of Giardia intestinalis in isolates from outbreaks in New Zealand.Infectious diseases of poverty · 2022Article
19 more citing papers are in PubMed but not listed here.
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11 authors.
Funding
Abstract
backgroundThe parasitic causes of diarrhea have historically been identified by use of microscopy; however, the use of this technique does not allow one to distinguish between subspecies or genotypes of parasites. Our objective was to determine, by use of modern diagnostic methods, the proportion of diarrhea cases in Bangladesh attributable to Cryptosporidium hominis, Cryptosporidium parvum, Entamoeba histolytica, and Giardia lamblia assemblages A and B.
methodsA prospective case-control study was performed involving 3646 case patients (both children and adults) who presented with diarrhea to the Dhaka hospital of the International Centre for Diarrhoeal Disease Research, Bangladesh, and 2575 control subjects with asymptomatic infection. Parasitic infection was detected by use of a stool parasite antigen test, and the parasite load and the species and/or genotypes were determined by use of polymerase chain reaction (PCR).
resultsCryptosporidium species and E. histolytica were more prevalent in patients with acute diarrhea than in healthy control subjects, for all ages (2.1% vs. 1.4%; P = .039) and, specifically, for those 0-12 months of age (2.2% vs. 0.4%; P = .009). G. lamblia assemblage A was also more prevalent in case patients with diarrhea than in healthy control subjects (20% vs. 5%; P = .001). For case patients with diarrhea, the parasite load in feces, as measured by quantitative real-time PCR cycle threshold, was not higher that that for control subjects with asymptomatic infection. Case patients with diarrhea and cryptosporidiosis were less likely to have abdominal pain, compared with control subjects (15% vs. 37%; P = .001); case patients with amebiasis more likely to have visible blood in stool, compared with control subjects (8% vs. 1.6%; P = .001); and case patients with giardiasis more likely to be dehydrated, compared with control subjects (81% vs. 71%; P = .001).
conclusionE. histolytica, C. hominis, C. parvum, and G. lamblia assemblage A infections are important causes of diarrheal illness in Bangladesh.
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