Evidence map›Paper›PMID 19322914›Full record

ReviewWorld journal of gastroenterology2009

Acute pancreatitis: etiology and common pathogenesis.

Guo-Jun Wang, Chun-Fang Gao, Dong Wei, Cun Wang, Si-Qin Ding

2 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 189 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
189citing papers in PubMed, 7 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07211568 phase3not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Pancreatic Enzyme Replacement Therapy on Nutrition in Acute Pancreatitis: A Multicenter Double Blinded Randomised Placebo Controlled Trial.

TypeinterventionalSponsorAsian Institute of Gastroenterology, IndiaRan2025 to 2027Enrolled188ConditionsAcute Pancreatitis Necrotizing, Nutrition AssessmentArmsPancreatic Enzyme Replacement Therapy, Placebo
NCT07441824 phase3recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of Pancreatic Enzyme Replacement Therapy in Patients With Acute Necrotizing Pancreatitis: A Multicenter Double Blinded Randomised Placebo Controlled Trial

TypeinterventionalSponsorAsian Institute of Gastroenterology, IndiaRan2026 to 2027Enrolled140ConditionsAcute Necrotizing Pancreatitis, Pancreatic Exocrine InsufficiencyArmsPancreatic enzyme capsules, Placebo
3 · Its place in the literature

Who cites it

189 citing papers in PubMed, 7 syntheses or guidelines pooled it, 420 citations in OpenAlex.

  1. Pooled it
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  5. Opioids for acute pancreatitis pain.The Cochrane database of systematic reviews · 2013
    Pooled it
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  7. Pooled it
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  11. CFTR IVS8 Poly-T Variation Affects Severity of Acute Pancreatitis in Women.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019
    Trial
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  14. Article
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  16. Diagnostic Performance of the Uric Acid-To-Albumin Ratio in Predicting Severity of Acute Pancreatitis.JGH open : an open access journal of gastroenterology and hepatology · 2026
    Article
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  19. Article
  20. Article

129 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guo-Jun WangInstitute of Digestive Surgery and Department of General Surgery, 150 Hospital of Chinese PLA, Gaoxin District, Luoyang 471031, Henan Province, China.
Chun-Fang Gao
Dong Wei
Cun Wang
Si-Qin Ding

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute pancreatitis is an inflammatory disease of the pancreas. The etiology and pathogenesis of acute pancreatitis have been intensively investigated for centuries worldwide. Many causes of acute pancreatitis have been discovered, but the pathogenetic theories are controversial. The most common cause of acute pancreatitis is gallstone impacting the distal common bile-pancreatic duct. The majority of investigators accept that the main factors for acute billiary pancreatitis are pancreatic hyperstimulation and bile-pancreatic duct obstruction which increase pancreatic duct pressure and active trypsin reflux. Acute pancreatitis occurs when intracellular protective mechanisms to prevent trypsinogen activation or reduce trypsin activity are overwhelmed. However, little is known about the other acute pancreatitis. We hypothesize that acute biliary pancreatitis and other causes of acute pancreatitis possess a common pathogenesis. Pancreatic hyperstimulation and pancreatic duct obstruction increase pancreatic duct pressure, active trypsin reflux, and subsequent unregulated activation of trypsin within pancreatic acinar cells. Enzyme activation within the pancreas leads to auto-digestion of the gland and local inflammation. Once the hypothesis is confirmed, traditional therapeutic strategies against acute pancreatitis may be improved. Decompression of pancreatic duct pressure should be advocated in the treatment of acute pancreatitits which may greatly improve its outcome.

Indexed as

Cholangiopancreatography, Endoscopic RetrogradeCholestasisGallstonesHumansInflammationPancreatic DuctsPancreatitisPancreatitis, Acute Necrotizing

Identifiers

PMID19322914
PMCPMC2665136
OpenAlexW2119496770

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.