ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2009
Enhanced flexor tendon healing through controlled delivery of PDGF-BB.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07659600 (Performance of Autologous Platelet-rich Plasma Injection for Tendon Regeneration in Partial Supraspinatus Tears), which is not on this map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Performance of Autologous Platelet-rich Plasma Injection for Tendon Regeneration in Partial Supraspinatus Tears
Who cites it
47 citing papers in PubMed, 109 citations in OpenAlex.
- Therapeutically Induced Modulation of Collagen I-to-III Ratio Three Weeks After Rabbit Achilles Tendon Full Transection.Biology · 2026Article
- Formulation-specific dose-response in the serum proteome of healthy dogs following cannabidiol administration.Frontiers in veterinary science · 2026Article
- One-Step Formed Janus Hydrogel with Time-Space Regulating Properties for Suture-Free and High-Quality Tendon Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Biomimetic Proteoglycans for Intervertebral Disc (IVD) Regeneration.Biomimetics (Basel, Switzerland) · 2024Review
- A Novel Bi-Directional and Bi-Temporal Delivery System for Enhancing Intrasynovial Tendon Repair.Materials and interfaces · 2024Article
- The effects of NF-κB suppression on the early healing response following intrasynovial tendon repair in a canine model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Drug Delivery Approaches to Improve Tendon Healing.Tissue engineering. Part B, Reviews · 2023Review
- Metabolic regulation of intrasynovial flexor tendon repair: The effects of dichloroacetate administration on early tendon healing in a canine model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- A Promising Candidate in Tendon Healing Events-PDGF-BB.Biomolecules · 2022Review
- Superior mechanical recovery in male and female MRL/MpJ tendons is associated with a unique genetic profile.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Fibrous Systems as Potential Solutions for Tendon and Ligament Repair, Healing, and Regeneration.Advanced healthcare materials · 2021Review
- Basic Research on Tendon Repair: Strategies, Evaluation, and Development.Frontiers in medicine · 2021Review
- Glycosaminoglycan-based biomaterials for growth factor and cytokine delivery: Making the right choices.Journal of controlled release : official journal of the Controlled Release Society · 2019Review
- Insulin-like growth factor 1 signaling in tenocytes is required for adult tendon growth.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Flexor Tendon: Development, Healing, Adhesion Formation, and Contributing Growth Factors.Plastic and reconstructive surgery · 2019Review
- The cellular basis of fibrotic tendon healing: challenges and opportunities.Translational research : the journal of laboratory and clinical medicine · 2019Review
- Effect of connective tissue growth factor delivered via porous sutures on the proliferative stage of intrasynovial tendon repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Growth factor delivery strategies for rotator cuff repair and regeneration.International journal of pharmaceutics · 2018Review
- Postnatal tendon growth and remodeling require platelet-derived growth factor receptor signaling.American journal of physiology. Cell physiology · 2018Article
- The effect of modified locking methods and suture materials on Zone II flexor tendon repair-An ex vivo study.PloS one · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
A fibrin/heparin-based delivery system was used to provide controlled delivery of platelet derived growth factor BB (PDGF-BB) in an animal model of intrasynovial flexor tendon repair. We hypothesized that PDGF-BB, administered in this manner, would stimulate cell proliferation and matrix remodeling, leading to improvements in the sutured tendon's functional and structural properties. Fifty-six flexor digitorum profundus tendons were injured and repaired in 28 dogs. Three groups were compared: (1) controlled delivery of PDGF-BB using a fibrin/heparin-based delivery system; (2) delivery system carrier control; and (3) repair- only control. The operated forelimbs were treated with controlled passive motion rehabilitation. The animals were euthanized at 7, 14, and 42 days, at which time the tendons were assessed using histologic (hyaluronic acid content, cellularity, and inflammation), biochemical (total DNA and reducible collagen crosslink levels), and biomechanical (gliding and tensile properties) assays. We found that cell activity (as determined by total DNA, collagen crosslink analyses, and hyaluronic acid content) was accelerated due to PDGF-BB at 14 days. Proximal interphalangeal joint rotation and tendon excursion (i.e., tendon gliding properties) were significantly higher for the PDGF-BB-treated tendons compared to the repair-alone tendons at 42 days. Improvements in tensile properties were not achieved, possibly due to suboptimal release kinetics or other factors. In conclusion, PDGF-BB treatment consistently improved the functional but not the structural properties of sutured intrasynovial tendons through 42 days following repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.