Evidence map›Paper›PMID 19322555›Full record

ReviewDer Nervenarzt2009

[Highly active antiretroviral therapy of neuro-AIDS. Side effects on the nervous system and interactions].

I W Husstedt, D Reichelt, E Neuen-Jakob, K Hahn, F Kästner, R von Einsiedel, B Vielhaber, G Arendt, S Evers

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Der Nervenarzt, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 1 country.

I W HusstedtKlinik und Poliklinik für Neurologie, Neuro-Aids-Ambulanz, Universitätsklinikum, Albert-Schweitzer-Strasse 33, 48129, Münster, Deutschland. husstedt@uni-muenster.de
D Reichelt
E Neuen-Jakob
K Hahn
F Kästner
R von Einsiedel
B Vielhaber
G Arendt
S Evers
Klinik und Poliklinik für Neurologie · DEAsklepios Klinik Langen · DECharité - Universitätsmedizin Berlin · DEDüsseldorf University Hospital · DEGerman Institute for Adult Education · DEHeinrich Heine University Düsseldorf · DEKlinik und Poliklinik für Psychiatrie und Psychotherapie · DEUniversity Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Highly active antiretroviral therapy (HAART) has increased the mean survival time in the AIDS stage to sometimes more than 10 years. Five different groups of antiretroviral medications are known, of which integrase inhibitors and CCR5 antagonists represent the newest and most modern substances. The long AIDS survival time implies that side effects and interactions become relatively more important and must be differentiated from the symptoms of HIV itself. Side effects of HAART concern the central and peripheral nervous system and the muscles. The neurotoxicity of the components in HAART varies considerably and depends on the substance itself. Knowledge of side effects and interactions of HAART with antiepileptics, antidepressants, and analgetics are essential for the treatment of patients with neuro-AIDS.

Indexed as

AIDS Dementia ComplexAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBrain DiseasesHumansPeripheral Nervous System DiseasesAnti-HIV Agents

Identifiers

PMID19322555
OpenAlexW1533155439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.