ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2009
The brattleboro rat displays a natural deficit in social discrimination that is restored by clozapine and a neurotensin analog.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 61 citations in OpenAlex.
- The role of vasopressin deficiency in the fluid intake suppression hyper-responsivity to central glucagon-like peptide-1 in the Brattleboro rat.Physiology & behavior · 2025Article
- Altered vocal communication in adult vasopressin-deficient Brattleboro rats.Physiology & behavior · 2024Article
- Vasopressin as Possible Treatment Option in Autism Spectrum Disorder.Biomedicines · 2023Review
- The role of glucagon-like peptide-1 (GLP-1) in fluid and food intakes in vasopressin-deficient Brattleboro rats.Physiology & behavior · 2023Article
- Preadolescent exposure to a sexually mature, unrelated male rat reduces postadolescent social recognition memory and CA2 c-Fos labeling.Frontiers in behavioral neuroscience · 2023Article
- Neurobehavioral Profiles of Six Genetically-based Rat Models of Schizophrenia- related Symptoms.Current neuropharmacology · 2023Article
- Vasopressin as a Possible Link between Sleep-Disturbances and Memory Problems.International journal of molecular sciences · 2022Review
- Transplantation of mesenchymal stem cells causes long-term alleviation of schizophrenia-like behaviour coupled with increased neurogenesis.Molecular psychiatry · 2021Article
- Endothelin neurotransmitter signalling controls zebrafish social behaviour.Scientific reports · 2019Article
- Neurotensin and neurotensin receptor 1 mRNA expression in song-control regions changes during development in male zebra finches.Developmental neurobiology · 2018Article
- Vasopressin deletion is associated with sex-specific shifts in the gut microbiome.Gut microbes · 2018Article
- Transplantation of mesenchymal stem cells reverses behavioural deficits and impaired neurogenesis caused by prenatal exposure to valproic acid.Oncotarget · 2017Article
- Song in an Affiliative Context Relates to the Neural Expression of Dopamine- and Neurotensin-Related Genes in Male European Starlings.Brain, behavior and evolution · 2016Article
- Patterns of Spontaneous Local Network Activity in Developing Cerebral Cortex: Relationship to Adult Cognitive Function.PloS one · 2015Article
- Repeated effects of the neurotensin receptor agonist PD149163 in three animal tests of antipsychotic activity: assessing for tolerance and cross-tolerance to clozapine.Pharmacology, biochemistry, and behavior · 2015Article
- Systemic administration of the neurotensin NTS₁-receptor agonist PD149163 improves performance on a memory task in naturally deficient male brown Norway rats.Experimental and clinical psychopharmacology · 2014Article
- Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders.Schizophrenia bulletin · 2014Article
- Social interaction and social withdrawal in rodents as readouts for investigating the negative symptoms of schizophrenia.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2014Review
- Effects of the neurotensin NTS₁ receptor agonist PD149163 on visual signal detection in rats.European journal of pharmacology · 2013Article
- Electroencephalographic and early communicative abnormalities in Brattleboro rats.Physiological reports · 2013Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Cognitive deficits in schizophrenia are a major source of dysfunction for which more effective treatments are needed. The vasopressin-deficient Brattleboro (BRAT) rat has been shown to have several natural schizophrenia-like deficits, including impairments in prepulse inhibition and memory. We investigated BRAT rats and their parental strain, Long-Evans (LE) rats, in a social discrimination paradigm, which is an ethologically relevant animal test of cognitive deficits of schizophrenia based upon the natural preference of animals to investigate conspecifics. We also investigated the effects of the atypical antipsychotic, clozapine, and the putative antipsychotic, PD149163, a brain-penetrating neurotensin-1 agonist, on social discrimination in these rats. Adult rats were administered saline or one of the three doses of clozapine (0.1, 1.0, or 10 mg/kg) or PD149163 (0.1, 0.3, or 1.0 mg/kg), subcutaneously. Following drug administration, adult rats were exposed to a juvenile rat for a 4-min learning period. Animals were then housed individually for 30 min and then simultaneously exposed to the juvenile presented previously and a new juvenile for 4 min. Saline-treated LE rats, but not BRAT rats, exhibited intact social discrimination as evidenced by greater time spent exploring the new juvenile. The highest dose of clozapine and the two highest doses of PD149163 restored social discrimination in BRAT rats. These results provide further support for the utility of the BRAT rat as a genetic animal model relevant to schizophrenia and drug discovery. The potential of neurotensin agonists as putative treatments for cognitive deficits of schizophrenia was also supported.
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