ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Nicotinic receptors concentrated in the subsynaptic membrane do not contribute significantly to synaptic currents at an embryonic synapse in the chicken ciliary ganglion.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Multiscale modeling of presynaptic dynamics from molecular to mesoscale.PLoS computational biology · 2022Article
- Segregation of glutamatergic and cholinergic transmission at the mixed motoneuron Renshaw cell synapse.Scientific reports · 2017Article
- Virtual leak channels modulate firing dynamics and synaptic integration in rat sympathetic neurons: implications for ganglionic transmission in vivo.The Journal of physiology · 2015Article
- α7-Containing and non-α7-containing nicotinic receptors respond differently to spillover of acetylcholine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Fast synaptic transmission in the goldfish CNS mediated by multiple nicotinic receptors.The Journal of physiology · 2011Article
- Lateral mobility of nicotinic acetylcholine receptors on neurons is determined by receptor composition, local domain, and cell type.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- PACAP/PAC1R signaling modulates acetylcholine release at neuronal nicotinic synapses.Molecular and cellular neurosciences · 2010Article
- Synchronous and asynchronous transmitter release at nicotinic synapses are differentially regulated by postsynaptic PSD-95 proteins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Characterization of rhythmic Ca2+ transients in early embryonic chick motoneurons: Ca2+ sources and effects of altered activation of transmitter receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Rapid synaptic transmission at the calyciform synapse in the embryonic chicken ciliary ganglion is mediated by two classes of nicotinic receptors: those containing alpha3 subunits [alpha3-nicotinic ACh receptors (nAChRs)] and those containing alpha7 subunits (alpha7-nAChRs). alpha3-nAChRs and alpha7-nAChRs are differentially distributed on the cell surface; alpha3-nAChRs are concentrated at postsynaptic densities, whereas both alpha7-nAChRs and alpha3-nAChRs are found extrasynaptically on somatic spines. I explored the contribution of alpha3-nAChRs and alpha7-nAChRs to uniquantal responses, measured as mEPSCs, or as evoked responses under low release probability conditions. The contribution that each nAChR makes to uniquantal response shape was determined by blocking one nAChR type; pharmacologically isolated alpha7-nAChR responses were kinetically fast (rise time, 0.32 +/- 0.02 ms; decay time, 1.66 +/- 0.18 ms; mean +/- SD; n = 6 cells), whereas pharmacologically isolated alpha3-nAChR responses were slow (rise time, 1.28 +/- 0.35 ms; decay time, 6.71 +/- 1.46 ms; n = 8 cells). In the absence of antagonists, most cells (11 of 14) showed heterogeneity in the kinetics of uniquantal responses, with approximately 25% of events exhibiting fast, alpha7-nAChR-like kinetics and approximately 75% of events exhibiting the kinetics expected of coactivation of alpha7-nAChRs and alpha3-nAChRs. Cells rarely showed significant numbers of uniquantal responses with slow, alpha3-nAChR-like kinetics, which was unexpected given that alpha3-nAChRs alone are concentrated at postsynaptic densities. The only site where ACh quanta can activate both alpha3-nAChRs and alpha7-nAChRs readily is on the somatic spines, where alpha7-nAChRs and alpha3-nAChRs are present extrasynaptically. At the calyciform synapse, rapid synaptic transmission is mediated apparently without participation of ionotropic receptors concentrated at postsynaptic densities.
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