ArticlePlant physiology2009
Loss of 26S proteasome function leads to increased cell size and decreased cell number in Arabidopsis shoot organs.
Article in Plant physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- When Size Matters: New Insights on How Seed Size Can Contribute to the Early Stages of Plant Development.Plants (Basel, Switzerland) · 2024Review
- Genetic variation in ZmKW1 contributes to kernel weight and size in dent corn and popcorn.Plant biotechnology journal · 2024Article
- The RPT2a-MET1 axis regulates TERMINAL FLOWER1 to control inflorescence meristem indeterminacy in Arabidopsis.The Plant cell · 2024Article
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- Genetic Localization and Homologous Genes Mining for Barley Grain Size.International journal of molecular sciences · 2023Review
- The soybean ubiquitin-proteasome system: Current knowledge and future perspective.The plant genome · 2023Review
- Integrative analysis of physiology, biochemistry and transcriptome reveals the mechanism of leaf size formation in Chinese cabbage (Frontiers in plant science · 2023Article
- Proteasome Dysfunction Leads to Suppression of the Hypoxic Response Pathway in Arabidopsis.International journal of molecular sciences · 2022Article
- Developing Genetic Engineering Techniques for Control of Seed Size and Yield.International journal of molecular sciences · 2022Review
- The RPN12a proteasome subunit is essential for the multiple hormonal homeostasis controlling the progression of leaf senescence.Communications biology · 2022Article
- Multi-omic analysis shows REVEILLE clock genes are involved in carbohydrate metabolism and proteasome function.Plant physiology · 2022Article
- The ubiquitin-26S proteasome system and autophagy relay proteome homeostasis regulation during silique development.The Plant journal : for cell and molecular biology · 2022Article
- Quantitative Proteomics ofPlants (Basel, Switzerland) · 2022Article
- Detection of a major QTL and development of KASP markers for seed weight by combining QTL-seq, QTL-mapping and RNA-seq in peanut.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Bidirectional mRNA transfer betweenFrontiers in plant science · 2022Article
- Genome-Wide Association Mapping of Seedling Biomass and Root Traits Under Different Water Conditions in Wheat.Frontiers in genetics · 2021Article
- Proteasomal Degradation of Proteins Is Important for the Proper Transcriptional Response to Sulfur Deficiency Conditions in Plants.Plant & cell physiology · 2020Article
- SMALL LEAF AND BUSHY1 controls organ size and lateral branching by modulating the stability of BIG SEEDS1 in Medicago truncatula.The New phytologist · 2020Article
- Genome-wide analysis of the rice J-protein family: identification, genomic organization, and expression profiles under multiple stresses.3 Biotech · 2019Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the final size of plant organs is influenced by environmental cues, it is generally accepted that the primary size determinants are intrinsic factors that regulate and coordinate cell proliferation and cell expansion. Here, we show that optimal proteasome function is required to maintain final shoot organ size in Arabidopsis (Arabidopsis thaliana). Loss of function of the subunit regulatory particle AAA ATPase (RPT2a) causes a weak defect in 26S proteasome activity and leads to an enlargement of leaves, stems, flowers, fruits, seeds, and embryos. These size increases are a result of increased cell expansion that compensates for a reduction in cell number. Increased ploidy levels were found in some but not all enlarged organs, indicating that the cell size increases are not caused by a higher nuclear DNA content. Partial loss of function of the regulatory particle non-ATPase (RPN) subunits RPN10 and RPN12a causes a stronger defect in proteasome function and also results in cell enlargement and decreased cell proliferation. However, the increased cell volumes in rpn10-1 and rpn12a-1 mutants translated into the enlargement of only some, but not all, shoot organs. Collectively, these data show that during Arabidopsis shoot development, the maintenance of optimal proteasome activity levels is important for balancing cell expansion with cell proliferation rates.
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