ArticleClinical and vaccine immunology : CVI2009
Tracking the emerging human pathogen Pseudallescheria boydii by using highly specific monoclonal antibodies.
Article in Clinical and vaccine immunology : CVI, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections.Clinical microbiology reviews · 2024Review
- Pulmonary pseudallescherioma in a 48-year-old woman with bronchiectasis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2024Article
- A Lateral-Flow Device for the Rapid Detection ofDiagnostics (Basel, Switzerland) · 2024Article
- Extracellularly Released Molecules by the Multidrug-Resistant Fungal Pathogens Belonging to theJournal of fungi (Basel, Switzerland) · 2022Review
- Review
- Pharmacodynamics of Voriconazole for Invasive Pulmonary Scedosporiosis.Antimicrobial agents and chemotherapy · 2018Article
- Ecology of Scedosporium Species: Present Knowledge and Future Research.Mycopathologia · 2018Review
- Molecular Imaging of Invasive Pulmonary Aspergillosis Using ImmunoPET/MRI: The Future Looks Bright.Frontiers in microbiology · 2018Review
- Tracking the amphibian pathogens Batrachochytrium dendrobatidis and Batrachochytrium salamandrivorans using a highly specific monoclonal antibody and lateral-flow technology.Microbial biotechnology · 2017Article
- Indoor Fungal Exposure and Allergic Respiratory Disease.Current allergy and asthma reports · 2015Review
- Purification and characterization of a mycelial catalase from Scedosporium boydii, a useful tool for specific antibody detection in patients with cystic fibrosis.Clinical and vaccine immunology : CVI · 2015Article
- Article
- Cerebral Scedosporium apiospermum infection presenting with intestinal manifestations.Infection · 2013Article
- Detection of invasive pulmonary aspergillosis in haematological malignancy patients by using lateral-flow technology.Journal of visualized experiments : JoVE · 2012Article
- The importance of a proper aetiological diagnosis in the management of patients with invasive mycoses: a case report of a brain abscess by Scedosporium apiospermum.Mycopathologia · 2011Article
- Monoclonal antibodies against peptidorhamnomannans of Scedosporium apiospermum enhance the pathogenicity of the fungus.PLoS neglected tropical diseases · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pseudallescheria boydii has long been known to cause white grain mycetoma in immunocompetent humans, but it has recently emerged as an opportunistic pathogen of humans, causing potentially fatal invasive infections in immunocompromised individuals and evacuees of natural disasters, such as tsunamis and hurricanes. The diagnosis of P. boydii is problematic since it exhibits morphological characteristics similar to those of other hyaline fungi that cause infectious diseases, such as Aspergillus fumigatus and Scedosporium prolificans. This paper describes the development of immunoglobulin M (IgM) and IgG1 kappa-light chain monoclonal antibodies (MAbs) specific to P. boydii and certain closely related fungi. The MAbs bind to an immunodominant carbohydrate epitope on an extracellular 120-kDa antigen present in the spore and hyphal cell walls of P. boydii and Scedosporium apiospermum. The MAbs do not react with S. prolificans, Scedosporium dehoogii, or a large number of clinically relevant fungi, including A. fumigatus, Candida albicans, Cryptococcus neoformans, Fusarium solani, and Rhizopus oryzae. The MAbs were used in immunofluorescence and double-antibody sandwich enzyme-linked immunosorbent assays (DAS-ELISAs) to accurately differentiate P. boydii from other infectious fungi and to track the pathogen in environmental samples. Specificity of the DAS-ELISA was confirmed by sequencing of the internally transcribed spacer 1 (ITS1)-5.8S-ITS2 rRNA-encoding regions of environmental isolates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.