Trial reportThe American journal of clinical nutrition2009
Dehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on bone.
Trial report in The American journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00182975 (Is DHEA Replacement Beneficial?), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Is DHEA Replacement Beneficial?
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Clinical review: The benefits and harms of systemic dehydroepiandrosterone (DHEA) in postmenopausal women with normal adrenal function: a systematic review and meta-analysis.The Journal of clinical endocrinology and metabolism · 2014Pooled it
- Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness.Aging cell · 2012Trial
- The effect of gonadal and adrenal steroid therapy on skeletal health in adolescents and young women with anorexia nervosa.Metabolism: clinical and experimental · 2012Trial
- Trial
- Imbalances in adrenal hormones and their effects on bone metabolism.Endocrine journal · 2025Review
- Impact of DHEA supplementation on testosterone and estradiol levels in postmenopausal women: a meta-analysis of randomized controlled trials assessing dose and duration effects.Diabetology & metabolic syndrome · 2025Review
- Dehydroepiandrosterone and Bone Health: Mechanisms and Insights.Biomedicines · 2024Review
- Sex-specific association of serum dehydroepiandrosterone and its sulfate levels with osteoporosis in type 2 diabetes.Journal of bone and mineral metabolism · 2024Article
- The historical context and scientific legacy of John O. Holloszy.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Review
- Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials.Clinical endocrinology · 2019Article
- Sex steroid actions in male bone.Endocrine reviews · 2014Review
- Dehydroepiandrosterone (DHEA): hypes and hopes.Drugs · 2014Review
- Testosterone increases circulating dehydroepiandrosterone sulfate levels in the male rhesus macaque.Frontiers in endocrinology · 2014Article
- Off-label use of hormones as an antiaging strategy: a review.Clinical interventions in aging · 2014Review
- A review of age-related dehydroepiandrosterone decline and its association with well-known geriatric syndromes: is treatment beneficial?Rejuvenation research · 2013Review
- Serum insulin-like growth factor-I is a marker for assessing the severity of vertebral fractures in postmenopausal women with type 2 diabetes mellitus.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 3 countries.
Funding
Abstract
backgroundAge-related reductions in serum dehydroepiandrosterone (DHEA) concentrations may be involved in bone mineral density (BMD) losses.
objectiveThe objective was to determine whether DHEA supplementation in older adults improves BMD when co-administered with vitamin D and calcium.
designIn year 1, a randomized trial was conducted in which men (n = 55) and women (n = 58) aged 65-75 y took 50 mg/d oral DHEA supplements or placebo. In year 2, all participants took open-label DHEA (50 mg/d). During both years, all participants received vitamin D (16 microg/d) and calcium (700 mg/d) supplements. BMD was measured by using dual-energy X-ray absorptiometry. Concentrations of hormones and bone turnover markers were measured in serum.
resultsIn men, no difference between groups occurred in any BMD measures or in bone turnover markers during year 1 or year 2. The free testosterone index and estradiol increased in the DHEA group only. In women, spine BMD increased by 1.7 +/- 0.6% (P = 0.0003) during year 1 and by 3.6 +/- 0.7% after 2 y of supplementation in the DHEA group; however, in the placebo group, spine BMD was unchanged during year 1 but increased to 2.6 +/- 0.9% above baseline during year 2 after the crossover to DHEA. Hip BMD did not change. Testosterone, estradiol, and insulin-like growth factor 1 increased in the DHEA group only. In both groups, serum concentrations of bone turnover markers decreased during year 1 and remained low during year 2, but did not differ between groups.
conclusionDHEA supplementation in older women, but not in men, improves spine BMD when co-administered with vitamin D and calcium. This trial was registered at clinicaltrials.gov as NCT00182975.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.