ArticleTuberculosis (Edinburgh, Scotland)2009
Strain specificity of antimycobacterial immunity in whole blood culture after cure of tuberculosis.
Article in Tuberculosis (Edinburgh, Scotland), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Development and application of the direct mycobacterial growth inhibition assay: a systematic review.Frontiers in immunology · 2024Pooled it
- Whole Blood Mycobacterial Growth Assays for Assessing Human Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis.Frontiers in immunology · 2021Pooled it
- Biomarker-assisted dose selection for safety and efficacy in early development of PNU-100480 for tuberculosis.Antimicrobial agents and chemotherapy · 2011Trial
- Evaluation of the Antibody in Lymphocyte Supernatant Assay to Detect Active Tuberculosis.PloS one · 2017Article
- Mycobacteria infect different cell types in the human lung and cause species dependent cellular changes in infected cells.BMC pulmonary medicine · 2016Article
- Plasma drug activity assay for treatment optimization in tuberculosis patients.Antimicrobial agents and chemotherapy · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Bactericidal assays have facilitated development of most modern vaccines, and have been proposed as indicators of protection after vaccination against tuberculosis. We examined control of intracellular growth of Mycobacterium tuberculosis in whole blood cultures of cured TB patients and tuberculin-negative healthy volunteers. Cured patients showed superior restriction of growth of the strain with which they had been infected. They similarly showed superior control of growth of a clinical strain (MP-28) that had become attenuated during passage. However, patients and healthy volunteers did not differ with regard to control of M. tuberculosis H37Ra. The ability of cured patients to control growth of the strain with which they had been infected correlated with MP-28, but not with H37Ra. These findings indicate M. tuberculosis MP-28 may be suitable to assess mycobacterial immunity as growth inhibition in whole blood culture, whereas H37Ra is not. However, additional studies will be required to confirm these observations in additional patient and microbial populations that are distinct according to geography and microbial and host genetics.
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Registered trials
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