ReviewCurrent opinion in immunology2009
Thymic maturation determines gammadelta T cell function, but not their antigen specificities.
Review in Current opinion in immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Phenotypic Remodeling of γδ T Cells in Non-Eosinophilic Chronic Rhinosinusitis with Nasal Polyposis.Medicina (Kaunas, Lithuania) · 2025Article
- The E protein-TCF1 axis controls γδ T cell development and effector fate.Cell reports · 2021Article
- The contribution of thymic tolerance to central nervous system autoimmunity.Seminars in immunopathology · 2021Review
- Review
- Transcription-Related Dynamics from Immune Disability into Endogenous Innovation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer.Investigative and clinical urology · 2019Article
- Donor Cell Composition and Reactivity Predict Risk of Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation.Journal of immunology research · 2016Article
- The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- γδ T cells are essential effectors of type 1 diabetes in the nonobese diabetic mouse model.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Increased cholesterol content in gammadelta (γδ) T lymphocytes differentially regulates their activation.PloS one · 2013Article
- PreTCR and TCRγδ signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization.Science signaling · 2011Article
- Deep sequencing of the human TCRγ and TCRβ repertoires suggests that TCRβ rearranges after αβ and γδ T cell commitment.Science translational medicine · 2011Article
- γδ T cell receptor ligands and modes of antigen recognition.Archivum immunologiae et therapiae experimentalis · 2011Review
- Roles of the NF-kappaB pathway in lymphocyte development and function.Cold Spring Harbor perspectives in biology · 2010Review
- Analysis of gamma delta T cell functions in the mouse.Journal of immunology (Baltimore, Md. : 1950) · 2010Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
gammadelta T cells contribute uniquely to host immune defense, but how they do so remains unclear. Recent work suggests that thymic selection does little to constrain gammadelta T cell antigen specificities, but instead determines their effector fate. When triggered through the T cell receptor, ligand-experienced cells make IFNgamma, whereas ligand-naïve gammadelta T cells produce IL-17, a major initiator of inflammation. These advances warrant a fresh look at how gammadelta T cells may function in the immune system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.