ArticleJournal of cellular and molecular medicine2009
Neural progenitors derived from human embryonic stem cells are targeted by allogeneic T and natural killer cells.
Article in Journal of cellular and molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 66 citations in OpenAlex.
- Cross-talk between human neural stem/progenitor cells and peripheral blood mononuclear cells in an allogeneic co-culture model.PloS one · 2015Trial
- Transplantation of neural stem progenitor cells from different sources for severe spinal cord injury repair in rat.Bioactive materials · 2023Article
- The Immunogenicity and Immune Tolerance of Pluripotent Stem Cell Derivatives.Frontiers in immunology · 2017Review
- MHC-class-II are expressed in a subpopulation of human neural stem cells in vitro in an IFNγ-independent fashion and during development.Scientific reports · 2016Article
- Human Parthenogenetic Embryonic Stem Cell-Derived Neural Stem Cells Express HLA-G and Show Unique Resistance to NK Cell-Mediated Killing.Molecular medicine (Cambridge, Mass.) · 2015Article
- Gene therapy using stem cells.Cold Spring Harbor perspectives in medicine · 2014Review
- Activating receptor NKG2D targets RAE-1-expressing allogeneic neural precursor cells in a viral model of multiple sclerosis.Stem cells (Dayton, Ohio) · 2014Article
- Survival of neural progenitors allografted into the CNS of immunocompetent recipients is highly dependent on transplantation site.Cell transplantation · 2014Article
- Immunological barriers to stem cell therapy in the central nervous system.Stem cells international · 2014Review
- Immunogenicity and tumorigenicity of pluripotent stem cells and their derivatives: genetic and epigenetic perspectives.Current stem cell research & therapy · 2014Review
- Natural killer cell-activating receptor NKG2D mediates innate immune targeting of allogeneic neural progenitor cell grafts.Stem cells (Dayton, Ohio) · 2013Article
- Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer.Investigative ophthalmology & visual science · 2013Article
- Concise review: immunologic lessons from solid organ transplantation for stem cell-based therapies.Stem cells translational medicine · 2013Review
- Immunogenicity of in vitro maintained and matured populations: potential barriers to engraftment of human pluripotent stem cell derivatives.Methods in molecular biology (Clifton, N.J.) · 2013Review
- How to cross immunogenetic hurdles to human embryonic stem cell transplantation.Seminars in immunopathology · 2011Review
- Effects of histocompatibility and host immune responses on the tumorigenicity of pluripotent stem cells.Seminars in immunopathology · 2011Review
- Potential barriers to therapeutics utilizing pluripotent cell derivatives: intrinsic immunogenicity of in vitro maintained and matured populations.Seminars in immunopathology · 2011Review
- Immunity of embryonic stem cell-derived hematopoietic progenitor cells.Seminars in immunopathology · 2011Review
- Stem cell sources for regenerative medicine: the immunological point of view.Seminars in immunopathology · 2011Review
- In vitro immunogenicity of undifferentiated pluripotent stem cells (PSC) and derived lineages.Seminars in immunopathology · 2011Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural progenitor cells (NPC) of foetal origin or derived from human embryonic stem cells (HESC) have the potential to differentiate into mature neurons after transplantation into the central nervous system, opening the possibility of cell therapy for neurodegenerative disorders. In most cases, the transplanted NPC are genetically unrelated to the recipient, leading to potential rejection of the transplanted cells. Very few data provide reliable information as to the potential immune response of allogeneic neural progenitors derived from HESC. In this study, we analyzed in vitro the allogeneic immune response of T lymphocytes and natural killer (NK) cells to NPC derived from HESC or of foetal origin. We demonstrate that NPC induce T-cell stimulation and a strong NK cytotoxic response. NK-cell activity is unrelated to MHC-I expression but driven by the activating NKG2D receptor. Cyclosporine and dexamethasone previously used in clinical studies with foetal NPC did not only fail to prevent NK alloreactivity but strongly inhibited the terminal maturation from NPC into mature neurons. We conclude that allogenic transplantation of NPC in the central nervous system will most likely require an immunosuppressive regimen targeting allogenic T and NK cells, whereas possible interference with the differentiation of NPC needs to be carefully evaluated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.