ArticleHistochemistry and cell biology2009
Evidence for distinct populations of human Merkel cells.
Article in Histochemistry and cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Increased expression of the PIEZO2 mechanoreceptor in fibroblasts and endothelial cells within the lymphatic and vascular vessels of keloids.The Journal of pathology · 2025Article
- How Merkel cells transduce mechanical stimuli: A biophysical model of Merkel cells.PLoS computational biology · 2023Article
- Emerging biomarker in carcinogenesis. Focus on Nestin.Postepy dermatologii i alergologii · 2022Review
- Review
- [Research advances on the function of skin touch receptor Merkel cells].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
- Review
- Identification of Merkel cells associated with neurons in engineered skin substitutes after grafting to full thickness wounds.PloS one · 2019Article
- Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development.PLoS genetics · 2016Article
- Unipotent, Atoh1+ progenitors maintain the Merkel cell population in embryonic and adult mice.The Journal of cell biology · 2015Article
- Merkel cells and touch domes: more than mechanosensory functions?Experimental dermatology · 2014Review
- Diversification and specialization of touch receptors in skin.Cold Spring Harbor perspectives in medicine · 2014Review
- Immunohistochemical analyses point to epidermal origin of human Merkel cells.Histochemistry and cell biology · 2014Article
- Sox2 modulates the function of two distinct cell lineages in mouse skin.Developmental biology · 2013Article
- Origin and regenerative potential of vertebrate mechanoreceptor-associated stem cells.Anatomy research international · 2012Article
- Which are the cells of origin in merkel cell carcinoma?Journal of skin cancer · 2012Article
- Merkel cell carcinoma: update and review.Seminars in cutaneous medicine and surgery · 2011Review
- Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biology.The American journal of pathology · 2010Article
- Extending the knowledge in histochemistry and cell biology.Histochemistry and cell biology · 2010Review
- Mammalian Merkel cells are descended from the epidermal lineage.Developmental biology · 2009Article
- Merkel cell carcinoma: recent progress and current priorities on etiology, pathogenesis, and clinical management.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2009Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Merkel cells (MCs) are neuroendocrine cells of unknown origin located in the skin. They are identified at electron microscopic level by electron dense granules, at light microscopic level by the presence of cytokeratins 8, 18, 19 and 20. Contradictory reports concerning the presence of other molecules of epithelial as well as neural origin prompted us to investigate whether there are distinct populations of human MCs. Here, we show the heterogeneous expression of villin, N-CAM, NGF-R, and neurofilaments in MCs. Synaptophysin is found in all MCs but with different intensity, nestin is absent. Expression patterns vary between interfollicular epidermis, hair follicles and glabrous epidermis. We conclude that there are distinct populations of MCs, but all populations contain markers for epithelial as well as neural cells. Putative functions of the distinct populations are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.