ArticleCancer immunology, immunotherapy : CII2009
Characterization of tumor antigen peptide-specific T cells isolated from the neoplastic tissue of patients with gastric adenocarcinoma.
Article in Cancer immunology, immunotherapy : CII, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- A comparative study of carbonic anhydrase activity in lymphocytes from colorectal cancer tissues and adjacent healthy counterparts.Journal of enzyme inhibition and medicinal chemistry · 2022Article
- Isolation of lymphocytes from the human gastric mucosa.World journal of methodology · 2021Review
- An integrative pan-cancer analysis of COPB1 based on data mining.Cancer biomarkers : section A of Disease markers · 2021Article
- Metabolomics profile in gastrointestinal cancers: Update and future perspectives.World journal of gastroenterology · 2020Review
- What's New in Gastric Cancer: The Therapeutic Implications of Molecular Classifications and Future Perspectives.International journal of molecular sciences · 2018Review
- Immunotherapeutic Strategies for Gastric Carcinoma: A Review of Preclinical and Clinical Recent Development.BioMed research international · 2017Review
- Host-Microbiome Interaction and Cancer: Potential Application in Precision Medicine.Frontiers in physiology · 2016Review
- Observational
- Gastric cancer and the epoch of immunotherapy approaches.World journal of gastroenterology · 2015Review
- Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy.Journal of immunology research · 2015Review
- Helicobacter pylori secreted peptidyl prolyl cis, trans-isomerase drives Th17 inflammation in gastric adenocarcinoma.Internal and emergency medicine · 2014Article
- Ex vivo analysis of pancreatic cancer-infiltrating T lymphocytes reveals that ENO-specific Tregs accumulate in tumor tissue and inhibit Th1/Th17 effector cell functions.Cancer immunology, immunotherapy : CII · 2013Article
- Immunotherapy for gastrointestinal malignancies.Cancer control : journal of the Moffitt Cancer Center · 2013Review
- T cells in gastric cancer: friends or foes.Clinical & developmental immunology · 2012Review
- T cells and adoptive immunotherapy: recent developments and future prospects in gastrointestinal oncology.Clinical & developmental immunology · 2011Review
- Novel immunotherapeutic strategies of gastric cancer treatment.Journal of biomedicine & biotechnology · 2011Review
- Research Progress of Immunotherapy for Gastric Cancer.Technology in cancer research & treatmentReview
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric cancer is a significant cause of morbidity and mortality worldwide. Surgical resection remains the primary curative treatment for gastric adenocarcinoma, but the poor (15-35%) survival rate at 5 years has prompted many studies for new therapeutic strategies, such as specific immunotherapy. The aim of this study was to analyze the functional properties of the T cell response to different antigen peptides related to gastric cancer in patients with gastric adenocarcinoma. To this purpose, we have cloned and characterized tumor-infiltrating T cells (TILs) isolated from the neoplastic gastric tissue samples. A T cell response specific to different peptides of gastric cancer antigens tested was documented in 17 out of 20 patients, selected for their HLA-A02 and/or -A24 alleles. Most of the cancer peptide-specific TILs expressed a Th1/Tc1 profile and cytotoxic activity against target cells. The effector functions of cancer peptide-specific T cells obtained from the peripheral blood of the same patients were also studied. The majority of peripheral blood peptide-specific T cells also expressed the Th1/Tc1 functional profile. In conclusion, in most of the patients with gastric adenocarcinoma, a specific type-1 T cell response to gastric cancer antigens was detectable and would have the potential of hamper tumor cell growth. However, in order to get tumor cell killing in vivo, the activity and the number of cancer peptide-specific Th1/Tc1 cells probably need to be enhanced by vaccination with the appropriate cancer antigenic peptides or by injection of the autologus tumor peptide-specific T cells expanded in vitro.
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