ArticleImmunogenetics2009
Trans-species polymorphism of the Mhc class II DRB-like gene in banded penguins (genus Spheniscus).
Article in Immunogenetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Genetic and evolutionary characteristics of the major histocompatibility complex class II β-chain genes of a large colony of captive king penguins (Aptenodytes patagonicus).Immunogenetics · 2026Article
- Distinct evolutionary trajectories of MHC class I and class II genes in Old World finches and buntings.Heredity · 2021Article
- Molecular Characterization of MHC Class I Genes in Four Species of theBioMed research international · 2021Article
- Article
- The role of demographic history and selection in shaping genetic diversity of the Galápagos penguin (Spheniscus mendiculus).PloS one · 2020Article
- Molecular characterization of MHC class IIB genes of sympatric Neotropical cichlids.BMC genetics · 2017Article
- Diversity of MHC class I alleles in Spheniscus humboldti.Immunogenetics · 2017Article
- Polymorphism in the major histocompatibility complex (MHC class II B) genes of the Rufous-backed Bunting (PeerJ · 2017Article
- Contrasting patterns of selection between MHC I and II across populations of Humboldt and Magellanic penguins.Ecology and evolution · 2016Article
- Contrasting evolutionary histories of MHC class I and class II loci in grouse--effects of selection and gene conversion.Heredity · 2016Article
- Diversity in the Toll-Like Receptor Genes of the African Penguin (Spheniscus demersus).PloS one · 2016Article
- Non-neutral evolution and reciprocal monophyly of two expressed Mhc class II B genes in Leach's storm-petrel.Immunogenetics · 2015Article
- Spatial and temporal variation at major histocompatibility complex class IIB genes in the endangered Blakiston's fish owl.Zoological letters · 2015Article
- Independent evolution of functional MHC class II DRB genes in New World bat species.Immunogenetics · 2012Article
- Evidence for evolutionary convergence at MHC in two broadly distributed mesocarnivores.Immunogenetics · 2012Article
- Characterization of MHC class I and II genes in a subantarctic seabird, the blue petrel, Halobaena caerulea (Procellariiformes).Immunogenetics · 2011Article
- Reduced MHC and neutral variation in the Galápagos hawk, an island endemic.BMC evolutionary biology · 2011Article
- Characterisation of class II B MHC genes from a ratite bird, the little spotted kiwi (Apteryx owenii).Immunogenetics · 2011Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Major Histocompatibility Complex (Mhc) class II DRB locus of vertebrates is highly polymorphic and some alleles may be shared between closely related species as a result of balancing selection in association with resistance to parasites. In this study, we developed a new set of PCR primers to amplify, clone, and sequence overlapping portions of the Mhc class II DRB-like gene from the 5'UTR end to intron 3, including exons 1, 2, and 3 and introns 1 and 2 in four species (20 Humboldt, six African, five Magellanic, and three Galapagos penguins) of penguin from the genus Spheniscus (Sphe). Analysis of gene sequence variation by the neighbor-joining method of 21 Sphe sequences and 20 previously published sequences from four other penguin species revealed overlapping clades within the Sphe species, but species-specific clades for the other penguin species. The overlap of the DRB-like gene sequence variants between the four Sphe species suggests that, despite their allopatric distribution, the Sphe species are closely related and that some shared DRB1 alleles may have undergone a trans-species inheritance because of balancing selection and/or recent rapid speciation. The new primers and PCR assays that we have developed for the identification of the DRB1 DNA and protein sequence variations appear to be useful for the characterization of the molecular evolution of the gene in closely related Penguin species and might be helpful for the assessment of the genetic health and the management of the conservation and captivity of these endangered species.
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