ArticleNature reviews. Immunology2009
Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?
Article in Nature reviews. Immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 169 citations in OpenAlex.
- Association of genetic polymorphisms of interleukins with gastric cancer and precancerous gastric lesions in a high-risk Chinese population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Trial
- The evolving landscape of IL-10, IL-22 and IL-26 in pleurisy especially in tuberculous pleurisy.Respiratory research · 2024Review
- Reciprocal costimulatory molecules control the activation of mucosal type 3 innate lymphoid cells during engagement with B cells.Cellular & molecular immunology · 2023Article
- Mucosa associated invariant T and natural killer cells in active and budesonide treated collagenous colitis patients.Frontiers in immunology · 2022Article
- Decidual CXCR4Clinical and translational medicine · 2021Article
- Role of Th22 Cells in Human Viral Diseases.Frontiers in medicine · 2021Review
- Innate Lymphoid Cells in Response to Intracellular Pathogens: ProtectionFrontiers in cellular and infection microbiology · 2021Review
- Interleukin-22 regulates gastric cancer cell proliferation through regulation of the JNK signaling pathway.Experimental and therapeutic medicine · 2020Article
- Mechanisms of Maintenance of Foot-and-Mouth Disease Virus Persistence Inferred From Genes Differentially Expressed in Nasopharyngeal Epithelia of Virus Carriers and Non-carriers.Frontiers in veterinary science · 2020Article
- A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Interleukin-22 (IL-22) Regulates Apoptosis of Paclitaxel-Resistant Non-Small Cell Lung Cancer Cells Through C-Jun N-Terminal Kinase Signaling Pathway.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Computational Analysis Supports an Early, Type 17 Cell-Associated Divergence of Blunt Trauma Survival and Mortality.Critical care medicine · 2016Article
- Interleukin-22 is elevated in lavage from patients with lung cancer and other pulmonary diseases.BMC cancer · 2016Article
- Innate immunity in vertebrates: an overview.Immunology · 2016Review
- Innate-like function of memory Th17 cells for enhancing endotoxin-induced acute lung inflammation through IL-22.International immunology · 2016Article
- Interleukin-22 promotes lung cancer cell proliferation and migration via the IL-22R1/STAT3 and IL-22R1/AKT signaling pathways.Molecular and cellular biochemistry · 2016Article
- IL-22 regulation of functional gene expression in salivary gland cells.Genomics data · 2016Article
- Activation of Natural Killer Cells by Probiotics.Forum on immunopathological diseases and therapeutics · 2016Article
- Airway epithelial NF-κB activation promotes the ability to overcome inhalational antigen tolerance.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Article
- The early intestinal immune response in experimental neonatal ovine cryptosporidiosis is characterized by an increased frequency of perforin expressing NCR1(+) NK cells and by NCR1(-) CD8(+) cell recruitment.Veterinary research · 2015Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mucosal tissues, lying at the interface with the external environment, are constantly challenged by microbial, physical and chemical assaults. To provide the necessary immune defence to such challenges, lymph nodes and Peyer's patches are formed in utero in response to inductive signals from lymphoid-tissue inducer (LTi) cells. As discussed in this Progress article, a series of recent reports has identified a population of interleukin-22-producing mucosal cells in the gut and tonsils that share features with both LTi cells (by expressing RORgammat) and natural killer cells (by expressing NKp46) and that might be involved in immunity and homeostasis in mucosal tissues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.