ReviewCurrent opinion in hematology2009
Cell adhesion and signaling networks in brain neurovascular units.
Review in Current opinion in hematology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 62 citations in OpenAlex.
- GlialeLife · 2026Article
- The β8 integrin cytoplasmic domain activates extracellular matrix adhesion to promote brain neurovascular development.Development (Cambridge, England) · 2022Article
- Drug Delivery Challenges in Brain Disorders across the Blood-Brain Barrier: Novel Methods and Future Considerations for Improved Therapy.Biomedicines · 2021Review
- Pathological changes in neurovascular units: Lessons from cases of vascular dementia.CNS neuroscience & therapeutics · 2021Review
- The pericyte: A critical cell in the pathogenesis of CADASIL.Cerebral circulation - cognition and behavior · 2021Review
- Microenvironmental Variations After Blood-Brain Barrier Breakdown in Traumatic Brain Injury.Frontiers in molecular neuroscience · 2021Review
- αvβ8 integrin adhesion and signaling pathways in development, physiology and disease.Journal of cell science · 2020Review
- Blockade of a Laminin-411-Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk.Cancer research · 2019Article
- Article
- Glioblastoma stem cells exploit the αvβ8 integrin-TGFβ1 signaling axis to drive tumor initiation and progression.Oncogene · 2017Article
- Selective expression of eGFP in mouse perivascular astrocytes by modification of the Mlc1 gene using T2A-based ribosome skipping.Genesis (New York, N.Y. : 2000) · 2017Article
- Neuropilin-1 modulates TGFβ signaling to drive glioblastoma growth and recurrence after anti-angiogenic therapy.PloS one · 2017Article
- Housing Complexity Alters GFAP-Immunoreactive Astrocyte Morphology in the Rat Dentate Gyrus.Neural plasticity · 2016Article
- Vascularisation of the central nervous system.Mechanisms of development · 2015Review
- Unsanctifying the sanctuary: challenges and opportunities with brain metastases.Neuro-oncology · 2015Review
- Protein tyrosine phosphatase-PEST and β8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells.Molecular and cellular biology · 2015Article
- Temporal-spatial correlation between angiogenesis and corticogenesis in the developing chick optic tectum.PloS one · 2015Article
- Cerebral artery signal transduction mechanisms: developmental changes in dynamics and Ca2+ sensitivity.Current vascular pharmacology · 2013Review
- Neurovascular development and links to disease.Cellular and molecular life sciences : CMLS · 2013Review
- αvβ8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion.Molecular biology of the cell · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewCentral nervous system (CNS) neurovascular units are multicellular complexes consisting of neurons and astrocytes, vascular endothelial cells and pericytes, as well as an assortment of growth factors and extracellular matrix (ECM) proteins. Here, I will discuss the current knowledge of signaling networks essential for the development and physiology of CNS neurovascular units, particularly in the brain. RECENT
findingsMolecular genetic studies have identified various signaling proteins that regulate the formation and function of CNS neurovascular units. These include members of the integrin family of ECM adhesion receptors, ECM proteins such as Wnts and latent transforming growth factor betas, and various transcriptional regulators, including beta-catenin and the inhibitors of DNA binding (Ids). SUMMARY: Neurovascular units are the cellular and molecular interfaces between the circulatory system and the CNS. Recent molecular genetic analyses in mice and other model organisms have revealed the first mechanisms underlying bidirectional communication between neural and vascular components. In particular, ECM-mediated adhesion and signaling pathways have been identified as essential for neurovascular development and physiology. Understanding how these various gene products normally control neurovascular unit formation and function will lend new insights into the causes and possible treatments of debilitating neurovascular-related diseases such as birth defects, stroke, and age-related dementia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.