ArticleMolecular & cellular proteomics : MCP2009
Identification of L-ferritin in neuromelanin granules of the human substantia nigra: a targeted proteomics approach.
Article in Molecular & cellular proteomics : MCP, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Combined enrichment of neuromelanin granules and synaptosomes from human substantia nigra pars compacta tissue for proteomic analysis.Journal of proteomics · 2013Trial
- Therapeutic Efficiency of Humic Acids in Intoxications.Life (Basel, Switzerland) · 2023Review
- Iron as the concert master in the pathogenic orchestra playing in sporadic Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2021Review
- Cognition and transcranial sonography in Parkinson's disease patients with or without orthostatic hypotension.Brain and behavior · 2021Article
- Noradrenergic correlates of chronic cocaine craving: neuromelanin and functional brain imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Proteomics in Human Parkinson's Disease: Present Scenario and Future Directions.Cellular and molecular neurobiology · 2019Review
- Regional Distributions of Iron, Copper and Zinc and Their Relationships With Glia in a Normal Aging Mouse Model.Frontiers in aging neuroscience · 2019Article
- Noradrenergic Dysfunction in Alzheimer's and Parkinson's Diseases-An Overview of Imaging Studies.Frontiers in aging neuroscience · 2018Review
- Neuromelanin organelles are specialized autolysosomes that accumulate undegraded proteins and lipids in aging human brain and are likely involved in Parkinson's disease.NPJ Parkinson's disease · 2018Article
- Brain Iron Metabolism Dysfunction in Parkinson's Disease.Molecular neurobiology · 2017Review
- Proteomic characterization of neuromelanin granules isolated from human substantia nigra by laser-microdissection.Scientific reports · 2016Article
- Iron and Neurodegeneration: Is Ferritinophagy the Link?Molecular neurobiology · 2016Review
- Preferential Extracellular Generation of the Active Parkinsonian Toxin MPP+ by Transporter-Independent Export of the Intermediate MPDP+.Antioxidants & redox signaling · 2015Article
- The role of iron in neurodegenerative disorders: insights and opportunities with synchrotron light.Frontiers in pharmacology · 2014Review
- Neuromelanin enhances the toxicity of α-synuclein in SK-N-SH cells.Journal of neural transmission (Vienna, Austria : 1996) · 2012Article
- Confirmation of functional zones within the human subthalamic nucleus: patterns of connectivity and sub-parcellation using diffusion weighted imaging.NeuroImage · 2012Article
- Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: preclinical Parkinson disease.Journal of neural transmission (Vienna, Austria : 1996) · 2011Review
- Microglia activation is related to substantia nigra echogenicity.Journal of neural transmission (Vienna, Austria : 1996) · 2010Article
- Basic mechanisms of neurodegeneration: a critical update.Journal of cellular and molecular medicine · 2010Review
- Mitochondrial therapy for Parkinson's disease: neuroprotective pharmaconutrition may be disease-modifying.Clinical pharmacology : advances and applications · 2010Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the pigmented dopaminergic neurons of the human substantia nigra pars compacta the system relevant in iron storage is the polymer neuromelanin (NM). Although in most cells this function is mainly accomplished by ferritin, this protein complex appears not to be expressed in NM-containing neurons. Nevertheless the conceivable presence of iron-storing proteins as part of the NM granules has recently been discussed on the basis of Mössbauer spectroscopy and synchrotron x-ray microspectroscopy. Intriguingly by combining subcellular fractionation of NM granules, peptide sequencing via tandem mass spectrometry, and the additional confirmation by multiple reaction monitoring and immunogold labeling for electron microscopy, L-ferritin could now be unambiguously identified and localized in NM granules for the first time. This finding not only supports direct evidence for a regulatory role of L-ferritin in neuroectodermal cell pigmentation but also integrates a new player within a complicated network governing iron homeostasis in the dopamine neurons of the human substantia nigra. Thus our finding entails far reaching implications especially when considering etiopathogenetic aspects of Parkinson disease.
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