ArticleRNA (New York, N.Y.)2009
The dawn of the RNA World: toward functional complexity through ligation of random RNA oligomers.
Article in RNA (New York, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Compositional memory matters for early molecular systems.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Evolution from Composome to RNA Replicase.Life (Basel, Switzerland) · 2026Review
- Exploring the space of self-reproducing ribozymes using generative models.Nature communications · 2025Article
- Polymerization and replication of primordial RNA induced by clay-water interface dynamics.Communications chemistry · 2025Article
- Selective Nonenzymatic Formation of Biologically Common RNA Hairpins.Angewandte Chemie (International ed. in English) · 2025Article
- Article
- Quasispecies productivity.Die Naturwissenschaften · 2024Article
- Three Biopolymers and Origin of Life Scenarios.Life (Basel, Switzerland) · 2024Review
- Did organs precede organisms in the origin of life?microLife · 2024Article
- Self-empowerment of life through RNA networks, cells and viruses.F1000Research · 2023Review
- Isoxazole Nucleosides as Building Blocks for a Plausible Proto-RNA.Angewandte Chemie (International ed. in English) · 2022Article
- Thermodynamic and Kinetic Sequence Selection in Enzyme-Free Polymer Self-Assembly inside a Non-equilibrium RNA Reactor.Life (Basel, Switzerland) · 2022Article
- A scenario for the emergence of protoviroids in the RNA world and for their further evolution into viroids and viroid-like RNAs by modular recombinations and mutations.Virus evolution · 2022Review
- Genome Evolution from Random Ligation of RNAs of Autocatalytic Sets.International journal of molecular sciences · 2021Article
- Enhanced Ribozyme-Catalyzed Recombination and Oligonucleotide Assembly in Peptide-RNA Condensates.Angewandte Chemie (International ed. in English) · 2021Article
- Viroids and the Origin of Life.International journal of molecular sciences · 2021Review
- Social Networking of Quasi-Species Consortia drive Virolution via Persistence.AIMS microbiology · 2021Review
- Thresholds in Origin of Life Scenarios.iScience · 2020Review
- Emergence of life in an inflationary universe.Scientific reports · 2020Article
- On the emergence of structural complexity in RNA replicators.RNA (New York, N.Y.) · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A main unsolved problem in the RNA World scenario for the origin of life is how a template-dependent RNA polymerase ribozyme emerged from short RNA oligomers obtained by random polymerization on mineral surfaces. A number of computational studies have shown that the structural repertoire yielded by that process is dominated by topologically simple structures, notably hairpin-like ones. A fraction of these could display RNA ligase activity and catalyze the assembly of larger, eventually functional RNA molecules retaining their previous modular structure: molecular complexity increases but template replication is absent. This allows us to build up a stepwise model of ligation-based, modular evolution that could pave the way to the emergence of a ribozyme with RNA replicase activity, step at which information-driven Darwinian evolution would be triggered.
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