Evidence map›Paper›PMID 19318290›Full record

ReviewCurrent opinion in microbiology2009

Inter-kingdom signaling: chemical language between bacteria and host.

Alline R Pacheco, Vanessa Sperandio

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed.

  1. Review
  2. Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Specificities of chemosensory receptors in the human gut microbiota.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Molecular Aspects of the Functioning of Pathogenic Bacteria Biofilm Based onInternational journal of molecular sciences · 2024
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. RepurposingAntibiotics (Basel, Switzerland) · 2022
    Article
  14. Computational and Biological Evaluation ofPharmaceuticals (Basel, Switzerland) · 2022
    Article
  15. Pharmacology of T2R Mediated Host-Microbe Interactions.Handbook of experimental pharmacology · 2022
    Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alline R PachecoDepartment of Microbiology and Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75390-9048, USA.
Vanessa Sperandio

Funding

AI-3 Inhibitors as treatment for bacterial infectionsU01AI077853 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2008 to 2012
$6.5M
Quorum sensing regulation of EHEC virulence genesR01AI053067 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2003 to 2017
$6.3M
NIAID NIH HHS R01 AI053067NIAID NIH HHS U01 AI077853
6 · The paper itself

Abstract

Chemical communication between cells ensures coordination of behavior. In prokaryotes, this chemical communication is usually referred to as quorum sensing, while eukaryotic cells signal through hormones. In the past years, a growing number of reports have shown that bacterial quorum sensing signals, called autoinducers, signal to eukaryotic cells, mimicking hormones. Conversely, host hormones can signal to bacterial cells through converging pathways to autoinducer signaling. This inter-kingdom signaling mediates symbiotic and pathogenic relationships between bacteria, mammalian and plant hosts.

Indexed as

Bacterial Physiological PhenomenaAnimalsBacterial ProteinsDrosophila ProteinsHormonesHost-Pathogen InteractionsHumansMammalsMembrane ProteinsPlant Physiological PhenomenaQuorum SensingSymbiosisTrans-ActivatorsBacterial ProteinsDrosophila ProteinsHormonesMembrane ProteinsRho protein, DrosophilaTrans-Activators

Identifiers

PMID19318290
PMCPMC4852728

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.