ReviewChemistry & biology2009
Frameworks for programming biological function through RNA parts and devices.
Review in Chemistry & biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- Review
- MicroRNA-21 guide and passenger strand regulation of adenylosuccinate lyase-mediated purine metabolism promotes transition to an EGFR-TKI-tolerant persister state.Cancer gene therapy · 2022Article
- Engineering synthetic RNA devices for cell control.Nature reviews. Genetics · 2022Review
- Rational design of hairpin RNA excited states reveals multi-step transitions.Nature communications · 2022Article
- Aptamers as Valuable Molecular Tools in Neurosciences.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- Synthetic Gene Expression Circuits for Designing Precision Tools in Oncology.Frontiers in cell and developmental biology · 2017Review
- Design and Construction of Generalizable RNA-Protein Hybrid Controllers by Level-Matched Genetic Signal Amplification.Cell systems · 2016Article
- Alternative Watson-Crick Synthetic Genetic Systems.Cold Spring Harbor perspectives in biology · 2016Review
- Opportunities in the design and application of RNA for gene expression control.Nucleic acids research · 2016Review
- Predictive analytics of environmental adaptability in multi-omic network models.Scientific reports · 2015Article
- Multi-objective optimization for RNA design with multiple target secondary structures.BMC bioinformatics · 2015Article
- Synthetic feedback control using an RNAi-based gene-regulatory device.Journal of biological engineering · 2015Article
- Synthetic biology: advancing the design of diverse genetic systems.Annual review of chemical and biomolecular engineering · 2013Review
- A high-throughput, quantitative cell-based screen for efficient tailoring of RNA device activity.Nucleic acids research · 2012Article
- Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways.Metabolic engineering · 2012Review
- Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing.Nature chemical biology · 2012Article
- Bacterial RNA thermometers: molecular zippers and switches.Nature reviews. Microbiology · 2012Review
- Twins, quadruplexes, and more: functional aspects of native and engineered RNA self-assemblyFrontiers in life science · 2012Article
- Synthetic biology: advancing biological frontiers by building synthetic systems.Genome biology · 2012Review
- Challenges and opportunities for small molecule aptamer development.Journal of nucleic acids · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
One of the long-term goals of synthetic biology is to reliably engineer biological systems that perform human-defined functions. Currently, researchers face several scientific and technical challenges in designing and building biological systems, one of which is associated with our limited ability to access, transmit, and control molecular information through the design of functional biomolecules exhibiting novel properties. The fields of RNA biology and nucleic acid engineering, along with the tremendous interdisciplinary growth of synthetic biology, are fueling advances in the emerging field of RNA programming in living systems. Researchers are designing functional RNA molecules that exhibit increasingly complex functions and integrating these molecules into cellular circuits to program higher-level biological functions. The continued integration and growth of RNA design and synthetic biology presents exciting potential to transform how we interact with and program biology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.