ReviewChemistry & biology2009
Recent progress toward the templated synthesis and directed evolution of sequence-defined synthetic polymers.
Review in Chemistry & biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 101 citations in OpenAlex.
- From liquid-phase synthesis to chemical ligation: preparation of oligonucleotides and their backbone analogs in solution.Nucleic acids research · 2025Review
- Chemical Information Processing by a Responsive Chemical System.Journal of the American Chemical Society · 2024Article
- Article
- Replication of a synthetic oligomer using chameleon base-pairs.Chemical communications (Cambridge, England) · 2022Article
- Spotting Trends in Organocatalyzed and Other Organomediated (De)polymerizations and Polymer Functionalizations.Angewandte Chemie (International ed. in English) · 2022Review
- Replication of Sequence Information in Synthetic Oligomers.Accounts of chemical research · 2021Article
- Evolution of sequence-defined highly functionalized nucleic acid polymers.Nature chemistry · 2018Article
- Molecular Biodynamers: Dynamic Covalent Analogues of Biopolymers.Accounts of chemical research · 2017Article
- DNA-encoded chemistry: enabling the deeper sampling of chemical space.Nature reviews. Drug discovery · 2017Review
- The structural diversity of artificial genetic polymers.Nucleic acids research · 2016Review
- The Toolbox for Modified Aptamers.Molecular biotechnology · 2016Review
- Refilling drug delivery depots through the blood.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Towards XNA nanotechnology: new materials from synthetic genetic polymers.Trends in biotechnology · 2014Review
- Single-chain technology using discrete synthetic macromolecules.Nature chemistry · 2011Article
- Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Evolution of synthetic polymers.Artificial DNA, PNA & XNA · 2010Article
- DNA as a versatile chemical component for catalysis, encoding, and stereocontrol.Angewandte Chemie (International ed. in English) · 2010Review
- Knitting complex weaves with DNA origami.Current opinion in structural biology · 2010Review
- CyDNA: synthesis and replication of highly Cy-dye substituted DNA by an evolved polymerase.Journal of the American Chemical Society · 2010Article
- Sequence-regulated vinyl copolymers by metal-catalysed step-growth radical polymerization.Nature communications · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Biological polymers such as nucleic acids and proteins are ubiquitous in living systems, but their ability to address problems beyond those found in nature is constrained by factors such as chemical or biological instability, limited building-block functionality, bioavailability, and immunogenicity. In principle, sequence-defined synthetic polymers based on nonbiological monomers and backbones might overcome these constraints; however, identifying the sequence of a synthetic polymer that possesses a specific desired functional property remains a major challenge. Molecular evolution can rapidly generate functional polymers but requires a means of translating amplifiable templates such as nucleic acids into the polymer being evolved. This review covers recent advances in the enzymatic and nonenzymatic templated polymerization of nonnatural polymers and their potential applications in the directed evolution of sequence-defined synthetic polymers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.