ArticleChemistry & biology2009
Designing new cellular signaling pathways.
Article in Chemistry & biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- STAT Signature Dish: Serving Immunity with a Side of Dietary Control.Biomolecules · 2025Review
- Synthetic Biology in Plants, a Boon for Coming Decades.Molecular biotechnology · 2021Review
- Signal transduction: From the atomic age to the post-genomic era.Cold Spring Harbor perspectives in biology · 2014Review
- Protein design for pathway engineering.Journal of structural biology · 2014Review
- TULIPs: tunable, light-controlled interacting protein tags for cell biology.Nature methods · 2012Article
- Cyclin-specific docking motifs promote phosphorylation of yeast signaling proteins by G1/S Cdk complexes.Current biology : CB · 2011Article
- BioNetCAD: design, simulation and experimental validation of synthetic biochemical networks.Bioinformatics (Oxford, England) · 2010Article
- Mapping the life histories of T cells.Nature reviews. Immunology · 2010Review
- Designing customized cell signalling circuits.Nature reviews. Molecular cell biology · 2010Review
- Building blocks for protein interaction devices.Nucleic acids research · 2010Article
- Strategies for protein synthetic biology.Nucleic acids research · 2010Review
- Towards genome-scale signalling network reconstructions.Nature reviews. Genetics · 2010Review
- Synthetic biology: tools to design, build, and optimize cellular processes.Journal of biomedicine & biotechnology · 2010Review
- A man-made ATP-binding protein evolved independent of nature causes abnormal growth in bacterial cells.PloS one · 2009Article
- Scaffolds: interaction platforms for cellular signalling circuits.Trends in cell biology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
All cells respond to signals from the environment. Extracellular stimuli activate intracellular signal transduction pathways that make decisions about cell identity, behavior, and survival. A nascent field aims to design and construct new signaling pathways beyond those found in nature. Current strategies exploit the structural modularity of many signaling proteins, which makes them inherently amenable to domain-swapping tactics that exchange their input and output connections. The results reveal a remarkable degree of functional plasticity in signaling proteins and pathways, as well as regulatory logic that can be transported to new proteins. Modified adaptor and scaffold proteins can reroute signal traffic and adjust the response behavior of the pathway circuit. These synthetic biology approaches promise to deepen our understanding of existing signaling pathways and spur the development of new cellular tools for research, industry, and medicine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.