ReviewChemistry & biology2009
Redesigning the architecture of the base pair: toward biochemical and biological function of new genetic sets.
Review in Chemistry & biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Stability and Reactivity of Alternative Nucleobases in Concentrated Sulfuric Acid.Molecules (Basel, Switzerland) · 2026Article
- 1Molecules (Basel, Switzerland) · 2024Article
- Stability and mechanism of threose nucleic acid toward acid-mediated degradation.Nucleic acids research · 2023Article
- Discovery of an Unnatural DNA Modification Derived from a Natural Secondary Metabolite.Cell chemical biology · 2021Article
- Unnatural bases for recognition of noncoding nucleic acid interfaces.Biopolymers · 2021Review
- Prebiotic chemistry in neutral/reduced-alkaline gas-liquid interfaces.Scientific reports · 2019Article
- Artificial genetic sets composed of size-expanded base pairs.Angewandte Chemie (International ed. in English) · 2013Review
- A chemical perspective on transcriptional fidelity: dominant contributions of sugar integrity revealed by unlocked nucleic acids.Angewandte Chemie (International ed. in English) · 2013Article
- Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a carbamoyl linker.Bioorganic & medicinal chemistry · 2013Article
- Cell-free biology: exploiting the interface between synthetic biology and synthetic chemistry.Current opinion in biotechnology · 2012Review
- Site-specific incorporation of functional components into RNA by an unnatural base pair transcription system.Molecules (Basel, Switzerland) · 2012Article
- Highly specific unnatural base pair systems as a third base pair for PCR amplification.Nucleic acids research · 2012Article
- Unnatural base pair systems toward the expansion of the genetic alphabet in the central dogma.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2012Review
- Encoding phenotype in bacteria with an alternative genetic set.Journal of the American Chemical Society · 2011Article
- Reversible bond formation enables the replication and amplification of a crosslinking salen complex as an orthogonal base pair.Nature chemistry · 2011Article
- Dynamic DNA nanotechnology using strand-displacement reactions.Nature chemistry · 2011Review
- Use of nucleic Acid analogs for the study of nucleic Acid interactions.Journal of nucleic acids · 2011Article
- Synthesis of 7-aza-5-deazapurine analogues via copper(I)-catalyzed hydroamination of alkynes and 1-iodoalkynes.The Journal of organic chemistry · 2010Article
- Toward a designed genetic system with biochemical function: polymerase synthesis of single and multiple size-expanded DNA base pairs.Organic & biomolecular chemistry · 2010Article
- Fluorescent analogs of biomolecular building blocks: design, properties, and applications.Chemical reviews · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Recognition of the nucleic acid bases within the DNA scaffold comprises the basis for transmission of genetic information, dictating protein and cell assembly, organismal development, and evolution. Driven in part by the need to test our current understanding of this information transfer, chemists have begun to design and synthesize nonnatural bases and base pair structures to mimic the function of DNA without relying on Nature's purine-pyrimidine base pair scaffold. Multiple examples have been recently described that self-assemble stably and sequence specifically in vitro, and some isolated unnatural base pairs can be replicated in vitro as well. Moreover, recent experiments with unnatural bases in bacterial cells have demonstrated surprisingly efficient reading of the chemical information. This suggests the future possibility of redesigning and replacing the chemical information of an evolving cell while retaining biological function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.