ArticleClinical biochemistry2009
Pediatric reference intervals for aldosterone, 17alpha-hydroxyprogesterone, dehydroepiandrosterone, testosterone and 25-hydroxy vitamin D3 using tandem mass spectrometry.
Article in Clinical biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 56 citations in OpenAlex.
- Choline supplementation alters some amino acid concentrations with no change in homocysteine in children with cystic fibrosis and pancreatic insufficiency.Nutrition research (New York, N.Y.) · 2016Trial
- A literature overview of age- and Tanner stage-specific reference intervals for sex hormones for children aged 0-18 years.Journal of molecular endocrinology · 2026Review
- Gonadal Function and Its Evolution in 46,XX Testicular/Ovotesticular DSD.The Journal of clinical endocrinology and metabolism · 2026Article
- Quantification of eight clinically relevant serum adrenal steroids in infants by UHPLC-APCI-MS/MS.Journal of mass spectrometry and advances in the clinical lab · 2025Article
- Early-in-Life Serum Aldosterone Levels Could Predict Surgery in Patients with Obstructive Congenital Anomalies of the Kidney and Urinary Tract: A Pilot Study.Journal of clinical medicine · 2023Article
- Continuous reference intervals for pediatric testosterone, sex hormone binding globulin and free testosterone using quantile regression.Journal of mass spectrometry and advances in the clinical lab · 2021Article
- Indirect Reference Intervals: Harnessing the Power of Stored Laboratory Data.The Clinical biochemist. Reviews · 2019Review
- Liquid Chromatography-Tandem Mass Spectrometry-Based Characterization of Steroid Hormone Profiles in Healthy 6 to 14-Year-Old Male Children.Chinese medical journal · 2018Article
- Reference intervals for plasma concentrations of adrenal steroids measured by LC-MS/MS: Impact of gender, age, oral contraceptives, body mass index and blood pressure status.Clinica chimica acta; international journal of clinical chemistry · 2017Article
- Accuracy-based proficiency testing for testosterone measurements with immunoassays and liquid chromatography-mass spectrometry.Clinica chimica acta; international journal of clinical chemistry · 2017Article
- Achievements and Future Directions of the APFCB Mass Spectrometry Harmonisation Project on Serum Testosterone.The Clinical biochemist. Reviews · 2016Review
- Vitamin D in plants: a review of occurrence, analysis, and biosynthesis.Frontiers in plant science · 2013Article
- Principles and clinical applications of liquid chromatography - tandem mass spectrometry for the determination of adrenal and gonadal steroid hormones.Journal of endocrinological investigation · 2011Review
- Steroid assays in paediatric endocrinology.Journal of clinical research in pediatric endocrinology · 2010Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo determine age and sex-specific pediatric reference intervals for aldosterone, 17alpha-hydroxyprogesterone, dehydroepiandrosterone, testosterone, and 25-hydroxy vitamin D(3). BACKGROUND AND
designReference intervals were determined for neonates and children 0-18 years of age. The study was conducted at both Children's National Medical Center and Georgetown University using outpatient blood samples obtained between January 1, 2004 and June 30, 2008.
methodsSerum samples were analyzed using isotope dilution liquid chromatography tandem mass spectrometry (LC/MS/MS) with deuterium-labeled internal standards at Children's National Medical Center and Georgetown University Medical Center Bioanalytical Core Laboratory. RESULTS AND
conclusionsThis is the first study to provide pediatric reference intervals of steroid hormones for children from birth to 18 years of age using LC/MS/MS. Reference intervals were established for aldosterone, 17alpha-hydroxyprogesterone, dehydroepiandrosterone, testosterone, and 25-hydroxy vitamin D(3). All the analytes exhibited at least some age dependence. Sex differences between early and late childhood and adolescence were found for 17alpha-hydroxyprogesterone and testosterone. Seasonal differences were apparent for 25-hydroxy vitamin D(3).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.