ArticleCancer2009
Lymph node ratio predicts disease-specific survival in melanoma patients.
Article in Cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 58 citations in OpenAlex.
- Safety and Feasibility of Minimally Invasive Inguinal Lymph Node Dissection in Patients With Melanoma (SAFE-MILND): Report of a Prospective Multi-institutional Trial.Annals of surgery · 2017Trial
- Therapeutic surgical management of palpable melanoma groin metastases: superficial or combined superficial and deep groin lymph node dissection.Annals of surgical oncology · 2011Trial
- Review
- Is there a relationship between length of resection and lymph-node ratio in colorectal cancer?Gastroenterology report · 2021Article
- Significance of lymph node ratio on survival of women with borderline ovarian tumors.Archives of gynecology and obstetrics · 2020Article
- Clinical Implications of Lymph Node Metastasis in Colorectal Cancer: Current Status and Future Perspectives.Annals of coloproctology · 2019Review
- Lymph node ratio has impact on relapse and outcome in patients with stage III melanoma.International journal of clinical oncology · 2019Article
- Lymph Node Ratio: Is It an Independent Prognostic Factor for Stage III Cutaneous Melanoma?Asian Pacific journal of cancer prevention : APJCP · 2018Article
- The impact of the lymph node ratio is greater than traditional lymph node status in stage III colorectal cancer patients.World journal of surgery · 2013Article
- Superficial and deep lymph node dissection for stage III cutaneous melanoma: clinical outcome and prognostic factors.World journal of surgical oncology · 2013Article
- N0/N1, PNL, or LNR? The effect of lymph node number on accurate survival prediction in pancreatic ductal adenocarcinoma.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2013Article
- Therapeutic lymph node dissection in melanoma: different prognosis for different macrometastasis sites?Annals of surgical oncology · 2012Article
- Inguinopelvic lymphadenectomy following positive inguinal sentinel lymph node biopsy in melanoma: true frequency of synchronous pelvic metastases.Annals of surgical oncology · 2011Article
- Interval sentinel lymph nodes: an unusual localization in patients with cutaneous melanoma.Dermatology research and practice · 2011Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe objectives of this analysis were to compare various measures associated with lymph node (LN) dissection and to identify threshold values associated with disease-specific survival (DSS) outcomes in patients with melanoma.
methodsPatients with lymph node-positive melanoma who underwent therapeutic LN dissection of the neck, axilla, and inguinal region were identified from the SEER database (1988-2005). We performed Cox multivariate analyses to determine the impact of the total number of LNs removed, number of negative LNs removed, and LN ratio on DSS. Multivariate cut-point analyses were conducted for each anatomic region to identify the threshold values associated with the largest improvement in DSS.
resultsThe LN ratio was significantly associated with DSS for all LN regions. The LN ratio thresholds resulting in the greatest difference in 5-year DSS were .07, .13, and .18 for neck, axillary, and inguinal regions, respectively, corresponding to 15, 8, and 6 LNs removed per positive lymph node. After adjustment for other clinicopathologic factors, the hazard ratios (HRs) were .53 (95% confidence interval [CI], .40 to .71) in the neck, .52 (95% CI, .42 to .65) in the axillary, and .47 (95% CI, .36 to .61) in the inguinal regions for patients who met the LN ratio threshold.
conclusionsAmong the prognostic factors examined, LN ratio was the best indicator of the extent of LN dissection, regardless of anatomic nodal region. These data provide evidence-based guidelines for defining adequate LN dissections in melanoma patients.
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