ArticleJournal of the American Chemical Society2009
Loosening and reorganization of fluid phospholipid bilayers by chloroform.
Article in Journal of the American Chemical Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Unmasking Conformationally Adaptable Lipids as Drug Receptors.Journal of medicinal chemistry · 2025Review
- Recent advances of medical polyhydroxyalkanoates in musculoskeletal system.Biomaterials translational · 2023Review
- Advances in Polyhydroxyalkanoate Nanocarriers for Effective Drug Delivery: An Overview and Challenges.Nanomaterials (Basel, Switzerland) · 2022Review
- Mechanistic Understanding from Molecular Dynamics in Pharmaceutical Research 2: Lipid Membrane in Drug Design.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Supramolecular Chemistry in the Biomembrane.Chembiochem : a European journal of chemical biology · 2020Review
- Use of nanoparticle concentration as a tool to understand the structural properties of colloids.Scientific reports · 2018Article
- Optimization of Magneto-thermally Controlled Release Kinetics by Tuning of Magnetoliposome Composition and Structure.Scientific reports · 2017Article
- Alteration of interleaflet coupling due to compounds displaying rapid translocation in lipid membranes.Scientific reports · 2016Article
- Chloroform alters interleaflet coupling in lipid bilayers: an entropic mechanism.Journal of the Royal Society, Interface · 2015Article
- Atomistic study of lipid membranes containing chloroform: looking for a lipid-mediated mechanism of anesthesia.PloS one · 2013Article
- Chloroform-enhanced incorporation of hydrophobic gold nanocrystals into dioleoylphosphatidylcholine (DOPC) vesicle membranes.Langmuir : the ACS journal of surfaces and colloids · 2012Article
- Halothane changes the domain structure of a binary lipid membrane.Langmuir : the ACS journal of surfaces and colloids · 2012Article
- Effects of isoflurane, halothane, and chloroform on the interactions and lateral organization of lipids in the liquid-ordered phase.Langmuir : the ACS journal of surfaces and colloids · 2011Article
- Phospholipid complexation of general anesthetics in fluid bilayers.Langmuir : the ACS journal of surfaces and colloids · 2010Article
- Using confocal laser scanning microscopy to probe the milk fat globule membrane and associated proteins.Journal of agricultural and food chemistry · 2010Article
- Activation of membrane cholesterol by 63 amphipaths.Biochemistry · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The mixing behavior of an exchangeable phospholipid (A) with an exchangeable sterol (B) in host bilayers made from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) containing varying concentrations of cholesterol has been examined via the nearest-neighbor recognition method. At low sterol concentrations (i.e., 2.5 mol %), the mixing between A and B is close to ideal. Incremental increases in the sterol concentration to 40 mol % led to net increases in the affinity between A and B. Similar mixing experiments that were carried out in the presence of chloroform showed a leveling effect, where moderate sterol-phospholipid affinity was observed in all cases. These results, together with the fact that the number of chloroform molecules that are absorbed per phospholipid is essentially constant and independent of the sterol content, support a model in which chloroform favors solvation of the phospholipids and a common membrane state is produced. Fluorescence measurements and Raman spectra have also shown that chloroform significantly loosens both cholesterol-poor and cholesterol-rich membranes made from DPPC. In a broader context, these results suggest a fundamentally new mechanism of anesthesia, where the anesthetic, by solvating the lipid components, profoundly changes the lateral organization of the lipid framework.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.