ArticleNeurocase2009
Sex-related functional asymmetry of the amygdala: preliminary evidence using a case-matched lesion approach.
Article in Neurocase, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gender and Hemispheric Asymmetries in Acquired Sociopathy.Frontiers in psychology · 2019Pooled it
- Mapping effective connectivity of human amygdala subdivisions with intracranial stimulation.Nature communications · 2022Article
- Risk-taking bias in human decision-making is encoded via a right-left brain push-pull system.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Let's call the whole thing off: evaluating gender and sex differences in executive function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Sex differences in the functional lateralization of emotion and decision making in the human brain.Journal of neuroscience research · 2017Review
- Sex-related functional asymmetry of the ventromedial prefrontal cortex in regard to decision-making under risk and ambiguity.Neuropsychologia · 2015Article
- Hemispheric side of damage influences sex-related differences in smoking cessation in neurological patients.Journal of clinical and experimental neuropsychology · 2014Article
- Effects of working memory load, a history of conduct disorder, and sex on decision making in substance dependent individuals.Drug and alcohol dependence · 2013Article
- Dimensions of personality disturbance after focal brain damage: investigation with the Iowa Scales of Personality Change.Journal of clinical and experimental neuropsychology · 2011Article
- The human amygdala is necessary for developing and expressing normal interpersonal trust.Neuropsychologia · 2011Article
- The amygdala and decision-making.Neuropsychologia · 2011Article
- Amygdala volume correlates positively with fearfulness in normal healthy girls.Social cognitive and affective neuroscience · 2010Article
- Effects of unilateral clefts on brain structure.Archives of pediatrics & adolescent medicine · 2010Article
- Sex-related functional asymmetry in the limbic brain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- Medial prefrontal cortex damage affects physiological and psychological stress responses differently in men and women.Psychoneuroendocrinology · 2010Article
- Declarative memory is critical for sustained advantageous complex decision-making.Neuropsychologia · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
We have reported previously that there appears to be an intriguing sex-related functional asymmetry of the prefrontal cortices, especially the ventromedial sector, in regard to social conduct, emotional processing, and decision-making, whereby the right-sided sector is important in men but not women and the left-sided sector is important in women but not men. The amygdala is another structure that has been widely implicated in emotion processing and social decision-making, and the question arises as to whether the amygdala, in a manner akin to what has been observed for the prefrontal cortex, might have sex-related functional asymmetry in regard to social and emotional functions. A preliminary test of this question was carried out in the current study, where we used a case-matched lesion approach and contrasted a pair of men cases and a pair of women cases, where in each pair one patient had left amygdala damage and the other had right amygdala damage. We investigated the domains of social conduct, emotional processing and personality, and decision-making. The results provide support for the notion that there is sex-related functional asymmetry of the amygdala in regard to these functions - in the male pair, the patient with right-sided amygdala damage was impaired in these functions, and the patient with left-sided amygdala damage was not, whereas in the female pair, the opposite pattern obtained, with the left-sided woman being impaired and the right-sided woman being unimpaired. These data provide preliminary support for the notion that sex-related functional asymmetry of the amygdala may entail functions such as social conduct, emotional processing, and decision-making, a finding that in turn could reflect (as either a cause or effect) differences in the manner in which men and women apprehend, process, and execute emotion-related information.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.