ArticleCancer microenvironment : official journal of the International Cancer Microenvironment Society2008
Matricellular proteins produced by melanocytes and melanomas: in search for functions.
Article in Cancer microenvironment : official journal of the International Cancer Microenvironment Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin.International journal of molecular sciences · 2023Review
- Exploration of hub genes, lipid metabolism, and the immune microenvironment in stomach carcinoma and cholangiocarcinoma.Annals of translational medicine · 2022Article
- Reproduction of patterns in melanocytic proliferations by agent-based simulation and geometric modeling.PLoS computational biology · 2021Article
- Elimination of classically-activated macrophages in tumor-conditioned medium by alternatively-activated macrophages.Biology open · 2017Article
- Targeting antisense mitochondrial ncRNAs inhibits murine melanoma tumor growth and metastasis through reduction in survival and invasion factors.Oncotarget · 2016Article
- Nanoparticle-mediated drug delivery for treating melanoma.Nanomedicine (London, England) · 2015Review
- Molecular pathology of cutaneous melanoma.Melanoma management · 2014Review
- SPARC/osteonectin is involved in metastatic process to the lung during melanoma progression.Virchows Archiv : an international journal of pathology · 2014Article
- Periostin cooperates with mutant p53 to mediate invasion through the induction of STAT1 signaling in the esophageal tumor microenvironment.Oncogenesis · 2013Article
- How do tenascins influence the birth and life of a malignant cell?Journal of cellular and molecular medicine · 2012Review
- Article
- Spatial-temporal modulation of CCN proteins during wound healing in human skin in vivo.Journal of cell communication and signaling · 2011Article
- Cancer biomarker discovery: the entropic hallmark.PloS one · 2010Article
- Proteomic analysis of laser microdissected melanoma cells from skin organ cultures.Journal of proteome research · 2010Article
- Regulatory role of CCN3 in melanoma cell interaction with the extracellular matrix.Cell adhesion & migrationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Matricellular proteins are modulators of cell-matrix interactions and cellular functions. The group includes thrombospondin, osteopontin, osteonectin/SPARC, tenascin, disintegrins, galectins and CCN proteins. The production of matricellular proteins such as osteopontin, SPARC or tenascin is highly upregulated in melanoma and other tumors but little is known about their functions in tumor growth, survival, and metastasis. The distribution pattern of CCN3 differs from most other matricellular proteins, such that it is produced abundantly by normal melanocytes, but is not significantly expressed in melanoma cells. CCN3 is known to inhibit melanocyte proliferation and stimulate adhesion to collagen type IV, the main component of the basement membrane. CCN3 has a unique role in securing adhesion of melanocytes to the basement membrane distinct from other melanoma-produced matricellular proteins which act as de-adhesive molecules and antagonists of focal adhesion. Qualitative and quantitative changes in matricellular protein expression contribute to melanoma progression similar to the E-cadherin to N-cadherin class switch, allowing melanoma cells to escape from keratinocyte control.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.