ArticleMammalian genome : official journal of the International Mammalian Genome Society2009
Two novel mouse genes mapped to chromosome Yp are expressed specifically in spermatids.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 27 citations in OpenAlex.
- Casting histone variants during mammalian reproduction.Chromosoma · 2023Review
- Return of the forgotten hero: the role of Y chromosome-encoded Zfy in male reproduction.Molecular human reproduction · 2023Article
- Novel Classes and Evolutionary Turnover of Histone H2B Variants in the Mammalian Germline.Molecular biology and evolution · 2022Article
- Biparental contributions of the H2A.B histone variant control embryonic development in mice.PLoS biology · 2020Article
- Evolutionary origins and diversification of testis-specific short histone H2A variants in mammals.Genome research · 2018Article
- SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation.Cell death and differentiation · 2017Article
- MS_HistoneDB, a manually curated resource for proteomic analysis of human and mouse histones.Epigenetics & chromatin · 2017Article
- Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Formation and Function in Assisted Fertilization.PLoS genetics · 2015Article
- Article
- Mouse Y-linked Zfy1 and Zfy2 are expressed during the male-specific interphase between meiosis I and meiosis II and promote the 2nd meiotic division.PLoS genetics · 2014Article
- Two Y genes can replace the entire Y chromosome for assisted reproduction in the mouse.Science (New York, N.Y.) · 2014Article
- Deficiency of the multi-copy mouse Y gene Sly causes sperm DNA damage and abnormal chromatin packaging.Journal of cell science · 2013Article
- Spermatid development in XO male mice with varying Y chromosome short-arm gene content: evidence for a Y gene controlling the initiation of sperm morphogenesis.Reproduction (Cambridge, England) · 2012Article
- Article
- A unified phylogeny-based nomenclature for histone variants.Epigenetics & chromatin · 2012Article
- Why chromosome palindromes?International journal of evolutionary biology · 2012Article
- A gene catalogue of the euchromatic male-specific region of the horse Y chromosome: comparison with human and other mammals.PloS one · 2011Article
- Histone variants in metazoan development.Developmental cell · 2010Review
- The multicopy gene Sly represses the sex chromosomes in the male mouse germline after meiosis.PLoS biology · 2009Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
The male-specific region of the Y chromosome is evolutionarily predisposed to accumulate genes important for spermatogenesis. Recent work in this laboratory identified two novel Y-linked transcripts that were upregulated in the testis in response to deletions on the chromosome arm Yq. This article reports the further characterisation of these two transcripts and their comparison to related X and autosomal genes. Both map to chromosome arm Yp, outside the Sxr ( b ) deletion interval, both are present in at least two copies on the Y, and both are expressed specifically in spermatids. Given the testicular phenotype of mice with deletions on the Y chromosome, both genes are therefore likely to function in spermatid differentiation. AK006152 is a novel mouse-specific gene with a single potential open reading frame, and it is unusual in that there appears to be no X-linked relative. H2al2y is a novel histone in the H2A superfamily and has multiple X-linked relatives and a single autosomal relative in mouse. The presence of a single X-linked copy in rat suggests that H2al amplification is mouse-specific, with the alternative explanation being an earlier amplification followed by gene loss. A phylogenetic analysis of H2al genes together with other H2A genes indicates that H2al is most closely related to the mammalian-specific H2A.Bbd family of histones. Interestingly, K (a)/K (s) analysis indicates that the X and Y members of the H2al family may be under positive selection in mouse, while the autosomal copy is under purifying selection and presumably retains the ancestral function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.